{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:19:39Z","timestamp":1785194379832,"version":"3.55.0"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We studied whether the serotypes of\n            <jats:italic>Mycobacterium avium-Mycobacterium intracellulare<\/jats:italic>\n            complex (MAC) isolates determine the prognosis for pulmonary MAC disease. We prospectively monitored a cohort of 68 patients with pulmonary MAC disease for whom the serotype-specific glycopeptidolipids in isolates were identified using thin-layer chromatography and fast atom bombardment mass-spectrometry in 1990 and 1995. Serovar 4\n            <jats:italic>Mycobacterium avium<\/jats:italic>\n            was detected in 40\/68 patients (58.8%). Other serotypes were serotypes 1 (five cases), 6 (three cases), 8 (seven cases), 9 (three cases), 14 (four cases), and 16 (six cases). Patients with serovar 4 were significantly (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01) younger (63.0 \u00b1 9.8 years) than patients with other serotypes (71.8 \u00b1 10.3). Patients who failed treatment had a significantly poorer prognosis than other patients. There were no cases of MAC-related death in the cured group. Chest radiographic findings progressively worsened in 36 (90%) of patients with serotype 4, and 14\/36 died from respiratory failure caused by pulmonary\n            <jats:italic>Mycobacterium avium<\/jats:italic>\n            disease. The patients with serotype 4 had a significantly poorer prognosis than patients with other serotypes. These results show that both the outcome of chemotherapy and the serotypes of MAC isolates are important for assessing the prognosis of pulmonary MAC disease.\n          <\/jats:p>","DOI":"10.1128\/jcm.43.7.3150-3158.2005","type":"journal-article","created":{"date-parts":[[2005,7,6]],"date-time":"2005-07-06T23:18:52Z","timestamp":1120691932000},"page":"3150-3158","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Clinical and Prognostic Importance of Serotyping\n            <i>Mycobacterium avium-Mycobacterium intracellulare<\/i>\n            Complex Isolates in Human Immunodeficiency Virus-Negative Patients"],"prefix":"10.1128","volume":"43","author":[{"given":"Ryoji","family":"Maekura","sequence":"first","affiliation":[{"name":"National Hospital Organization, Toneyama National Hospital, Toyonaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Okuda","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Toneyama National Hospital, Toyonaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsusi","family":"Hirotani","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Toneyama National Hospital, Toyonaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seigo","family":"Kitada","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Toneyama National Hospital, Toyonaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Touru","family":"Hiraga","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Toneyama National Hospital, Toyonaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Toneyama National Hospital, Toyonaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuya","family":"Yano","sequence":"additional","affiliation":[{"name":"Japan BCG Laboratory, Kiyose, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Host Defense, Osaka City University Graduate School of Medicine, Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Ito","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Toneyama National Hospital, Toyonaka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.4.940"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.1.ed08-97"},{"key":"e_1_3_1_4_2","first-page":"549","volume":"22","year":"1968","unstructured":"Ardalan, P. 1968. 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