{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:20:32Z","timestamp":1792678832812,"version":"4.5.0"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Clinical and microbiologic studies of 50 cases of viridans streptococcal bacteremia in cancer patients were performed. The bacteria were identified to species level by sequencing analysis of the 16S rRNA gene. At least nine\n            <jats:italic>Streptococcus<\/jats:italic>\n            spp. were found, including\n            <jats:italic>S. mitis<\/jats:italic>\n            (25 strains, 50.0% of 50); currently unnamed\n            <jats:italic>Streptococcus<\/jats:italic>\n            spp. (11 strains);\n            <jats:italic>S. parasanguis<\/jats:italic>\n            (five strains);\n            <jats:italic>S. anginosus<\/jats:italic>\n            (three strains);\n            <jats:italic>S. salivarius<\/jats:italic>\n            (two strains); and one strain each of\n            <jats:italic>S. gordonii, S. sanguis, S. sobrinus<\/jats:italic>\n            , and\n            <jats:italic>S. vestibularis<\/jats:italic>\n            . There were no\n            <jats:italic>S. oralis<\/jats:italic>\n            strains. Among 11 antibiotics of nine classes tested, no resistance to vancomycin, linezolid, or quinupristin-dalfopristin was seen. Resistance to penicillin (MIC, 4 to 12 \u03bcg\/ml) was noted only among\n            <jats:italic>S. mitis<\/jats:italic>\n            strains (28.0%, 7\/25) and not non-\n            <jats:italic>S. mitis<\/jats:italic>\n            strains (0\/25) (\n            <jats:italic>P<\/jats:italic>\n            = 0.004). Significantly more\n            <jats:italic>S. mitis<\/jats:italic>\n            strains than non-\n            <jats:italic>S. mitis<\/jats:italic>\n            strains were resistant to fluoroquinolones and to \u22653 classes of antibiotics. Isolation of quinolone-resistant organisms was associated with the prior usage of quinolones (\n            <jats:italic>P<\/jats:italic>\n            = 0.002). Quantitative blood cultures showed that the strains resistant to levofloxacin or gatifloxacin were associated with higher colony counts than were their corresponding nonresistant strains. The young and elderly patients also had higher levels of bacteremia caused predominantly by\n            <jats:italic>S. mitis<\/jats:italic>\n            . Septic shock was present in 17 (34.0% of 50) patients, and 13 of those cases were caused by\n            <jats:italic>S. mitis<\/jats:italic>\n            (\n            <jats:italic>P<\/jats:italic>\n            = 0.007). These results suggest that\n            <jats:italic>S. mitis<\/jats:italic>\n            is the most common cause of viridans streptococcal bacteremia in cancer patients and is more resistant to antibiotics than other species.\n          <\/jats:p>","DOI":"10.1128\/jcm.44.1.160-165.2006","type":"journal-article","created":{"date-parts":[[2006,1,3]],"date-time":"2006-01-03T18:43:05Z","timestamp":1136313785000},"page":"160-165","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":115,"title":["Viridans Streptococci Isolated by Culture from Blood of Cancer Patients: Clinical and Microbiologic Analysis of 50 Cases"],"prefix":"10.1128","volume":"44","author":[{"given":"Xiang Y.","family":"Han","sequence":"first","affiliation":[{"name":"Section of Clinical Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallika","family":"Kamana","sequence":"additional","affiliation":[{"name":"Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth V. I.","family":"Rolston","sequence":"additional","affiliation":[{"name":"Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/08880010390220144"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.624-626.2001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-40-3-202"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-41-4-487"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.4.840-862.2004"},{"key":"e_1_3_2_8_2","unstructured":"Performance standards for antimicrobial susceptibility testing; 15th informational supplement 2005 vol. 25(1)"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.4.891"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-39-3-179"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.10.3623-3630.2000"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.6.1201"},{"key":"e_1_3_2_13_2","first-page":"572","volume":"35","year":"2004","unstructured":"Gomes, M. F., R. T. Teixeira, G. Plens, M. M. Silva, E. M. Pontes, and J. C. da Rocha. 2004. Naso-orbicular tissue necrosis by Streptococcus parasanguis in a patient with Fanconi anemia: clinical and laboratory aspects. Quintessence Int.35:572-576.","journal-title":"Quintessence Int."},{"key":"e_1_3_2_14_2","unstructured":"Advanced techniques in diagnostic microbiology"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1309\/HN44-XQYM-JMAQ-2EDL"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(95)00137-Y"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-49-1-55"},{"key":"e_1_3_2_18_2","first-page":"2434","year":"2005","unstructured":"Johnson, C. C., and A. R. Tunkel. 2005. Viridans streptococci, groups C and G streptococci, and Gemella morbillorum. p. 2434-2451. In G. L. Mandell, J. E. Bennett, and R. Dolin (ed.), Principles and practice of infectious diseases, 6th ed. Churchill Livingstone, Inc., Philadelphia, Pa.","journal-title":"Principles and practice of infectious diseases"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-45-2-406"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-48-3-921"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.2.558-563.2003"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0742-2822.2004.02171.x"},{"key":"e_1_3_2_23_2","first-page":"49","year":"2001","unstructured":"Ludwig, W., and H.-P. Klenk. 2001. Overview: a phylogenetic backbone and taxonomic framework for prokaryotic systematics, p. 49-65. In D. R. Boone, R. W. Castenholz, and G. M. Garrity (ed.), Bergey's manual of systematic bacteriology, 2nd ed., vol. I. The archae and the deeply branching and phototrophic bacteria. Springer-Verlag, New York, N.Y.","journal-title":"Bergey's manual of systematic bacteriology"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/317460"},{"key":"e_1_3_2_25_2","first-page":"799","year":"2001","unstructured":"Munford, R. S. 2001. Sepsis and septic shock, p. 799-804. In E. Braunwald, A. S. Fauci, D. L. Kasper, S. L. Hauser, D. L. Longo, and J. L. Jameson (ed.), Harrison's principles of internal medicine, 15th ed. McGraw-Hill, Inc., New York, N.Y.","journal-title":"Harrison's principles of internal medicine"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.7.3023-3029.2004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00272-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.12.3770-3783.2001"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/340352"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90117-5"},{"key":"e_1_3_2_31_2","first-page":"405","year":"2003","unstructured":"Ruoff, K. L., R. A. Whiley, and D. Beighton. 2003. Streptococcus, p. 405-421. In P. R. Murray, E. J. Baron, J. H. Jorgensen, M. A. Pfaller, and R. H. Yolken (ed.), Manual of clinical microbiology, 8th ed. ASM Press, Washington, D.C.","journal-title":"Manual of clinical microbiology"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.10.2245-2249.1991"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/340402"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.1.40"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.6.2275-2278.2003"},{"key":"e_1_3_2_36_2","first-page":"115","volume":"56","year":"1990","unstructured":"Whiley, R. A., H. Y. Fraser, C. W. Douglas, J. M. Hardie, A. M. Williams, and M. D. Collins. 1990. Streptococcus parasanguis sp. nov., an atypical viridans Streptococcus from human clinical specimens. FEMS Microbiol. Lett.56:115-121.","journal-title":"FEMS Microbiol. Lett."}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.44.1.160-165.2006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.44.1.160-165.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T04:37:49Z","timestamp":1646455069000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.44.1.160-165.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1128\/JCM.44.1.160-165.2006"],"URL":"https:\/\/doi.org\/10.1128\/jcm.44.1.160-165.2006","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2005-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}