{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:20:23Z","timestamp":1790551223125,"version":"4.1.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Neurological infections due to rapidly growing mycobacteria (RGM) have rarely been reported. We recently investigated two unrelated immunocompetent patients, one with community-acquired lymphocytic meningitis and the other with cerebral thrombophlebitis.\n            <jats:italic>Mycobacterium mucogenicum<\/jats:italic>\n            was isolated in pure culture and detected by PCR sequencing of cerebrospinal fluid samples. Both patients eventually died. The two isolates exhibited an overlapping antimicrobial susceptibility pattern. They were susceptible in vitro to tetracyclines, macrolides, quinolones, amikacin, imipenem, cefoxitin, and trimethoprim-sulfamethoxazole and resistant to ceftriaxone. They shared 100% 16S rRNA gene sequence similarity with\n            <jats:italic>M. mucogenicum<\/jats:italic>\n            ATCC 49650\n            <jats:sup>T<\/jats:sup>\n            over 1,482 bp. Their partial\n            <jats:italic>rpoB<\/jats:italic>\n            sequences shared 97.8% and 98.1% similarity with\n            <jats:italic>M. mucogenicum<\/jats:italic>\n            ATCC 49650\n            <jats:sup>T<\/jats:sup>\n            , suggesting that the two isolates were representative of two sequevars of\n            <jats:italic>M. mucogenicum<\/jats:italic>\n            species. This case report should make clinicians aware that\n            <jats:italic>M. mucogenicum<\/jats:italic>\n            , an RGM frequently isolated from tap water or from respiratory specimens and mostly without clinical significance, can even be encountered in the central nervous system of immunocompetent patients.\n          <\/jats:p>","DOI":"10.1128\/jcm.44.3.837-840.2006","type":"journal-article","created":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T22:28:19Z","timestamp":1141424899000},"page":"837-840","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Report of Two Fatal Cases of\n            <i>Mycobacterium mucogenicum<\/i>\n            Central Nervous System Infection in Immunocompetent Patients"],"prefix":"10.1128","volume":"44","author":[{"given":"Toi\u0308di","family":"Ade\u0301kambi","sequence":"first","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020 IFR 48, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, and Assistance Publique-Ho\u0302pitaux de Marseille Timone Fe\u0301de\u0301ration de Microbiologie Clinique, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Foucault","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020 IFR 48, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, and Assistance Publique-Ho\u0302pitaux de Marseille Timone Fe\u0301de\u0301ration de Microbiologie Clinique, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"La Scola","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020 IFR 48, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, and Assistance Publique-Ho\u0302pitaux de Marseille Timone Fe\u0301de\u0301ration de Microbiologie Clinique, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Drancourt","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020 IFR 48, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, and Assistance Publique-Ho\u0302pitaux de Marseille Timone Fe\u0301de\u0301ration de Microbiologie Clinique, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.12.5699-5708.2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.63094-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.12.5493-5501.2004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Ad\u00e9kambi T. 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