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Thirty-four proteins exhibited significant reactivity when assayed with human sera from patients in the early latent stage of syphilis. A subset of antigens identified were further scrutinized for antibody reactivity at primary, secondary, and latent disease stages, and the results demonstrate that the humoral immune response to individual<jats:italic>T. pallidum<\/jats:italic>proteins develops at different rates during the time course of infection.<\/jats:p>","DOI":"10.1128\/jcm.44.3.888-891.2006","type":"journal-article","created":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T22:28:19Z","timestamp":1141424899000},"page":"888-891","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":66,"title":["Reactivity of Antibodies from Syphilis Patients to a Protein Array Representing the<i>Treponema pallidum<\/i>Proteome"],"prefix":"10.1128","volume":"44","author":[{"given":"Mary Beth","family":"Brinkman","sequence":"first","affiliation":[{"name":"Department of Molecular Virology and Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"McKevitt","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"McLoughlin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrilyn","family":"Howell","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine"},{"name":"Department of Microbiology and Molecular Genetics, University of Texas\u2014Houston Medical School, 6431 Fannin Street, Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Palzkill","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.4.1381-1391.1994"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.12.3556-3562.1995"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.23.6685-6692.1996"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/315399"},{"key":"e_1_3_2_6_2","first-page":"1117","volume":"52","year":"2003","unstructured":"Centers for Disease Control and Prevention. 2003. 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