{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:11:32Z","timestamp":1789132292883,"version":"build-2803163510"},"reference-count":21,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Microbiol Biol Educ."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Immunology is a conceptually challenging subject due to its multi-level organization and dynamic, non-linear processes. Medical students often struggle to integrate molecular mechanisms, cellular interactions, and system-level responses into a coherent understanding. While collaborative learning can enhance engagement, approaches that explicitly support multi-scale mechanistic reasoning and systems thinking in immunology education remain underexplored. We conducted a qualitative curriculum case study of a scaffolded, jigsaw-style, artifact-centered capstone activity embedded within a required undergraduate medical immunology course (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 27). Five student groups were assigned complementary conceptual dimensions representing spatial, molecular, cellular, temporal, and regulatory aspects of immune function. Guided by a shared \u201cImmune Kingdom\u201d metaphor, students developed multimodal artifacts that were iteratively refined through instructor feedback and synthesized into the Immune Panorama. Evidence was drawn from student-generated artifacts, instructor assessment, and a post-course questionnaire. Student-generated artifacts demonstrated complementary representations of immune organization across spatial, molecular, cellular, temporal, and regulatory dimensions. Instructor-guided refinement helped students correct conceptual ambiguities and strengthen mechanistic connections within their artifacts. In the post-course questionnaire, students reported that the activity supported system-level understanding, mechanistic learning, visualization of complex immune processes, and collaborative learning. Collectively, the five group artifacts were synthesized into the Immune Panorama, a shared conceptual framework representing immune function across multiple biological scales. This curriculum demonstrates that a jigsaw-style, artifact-centered learning design can support the development of integrated, multi-scale understanding in undergraduate immunology. Through collaborative construction of the Immune Panorama, students engaged in systems thinking and multi-scale mechanistic reasoning. The framework provides a practical curricular model that may be adapted to other biomedical and life science disciplines requiring integration of complex biological systems.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/jmbe.00111-26","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:01:08Z","timestamp":1789131668000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Constructing the Immune Panorama: a jigsaw-style, artifact-centered approach to teaching immunology"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-2012","authenticated-orcid":true,"given":"Huan","family":"Ren","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/000qzf213","id-type":"ROR","asserted-by":"publisher"}],"name":"Immunology Division, School of Medicine, Southern University of Science & Technology","place":["Shenzhen, China"]},{"id":[{"id":"https:\/\/ror.org\/049tv2d57","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, School of Medicine, Southern University of Science & Technology","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijin","family":"Shen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/000qzf213","id-type":"ROR","asserted-by":"publisher"}],"name":"Immunology Division, School of Medicine, Southern University of Science & Technology","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/000qzf213","id-type":"ROR","asserted-by":"publisher"}],"name":"Immunology Division, School of Medicine, Southern University of Science & Technology","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3410-9461","authenticated-orcid":true,"given":"Qiao","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/000qzf213","id-type":"ROR","asserted-by":"publisher"}],"name":"Immunology Division, School of Medicine, Southern University of Science & Technology","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyong","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/000qzf213","id-type":"ROR","asserted-by":"publisher"}],"name":"Pathology Division, School of Medicine, Southern University of Science & Technology","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12909-019-1786-5"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/09500693.2023.2300380"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02446"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/2331186X.2017.1398705"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.2100030"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00244.2020"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40594-016-0047-y"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/sce.20235"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15327809jls1402_1"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/sce.21301"},{"key":"e_1_3_5_12_2","volume-title":"The jigsaw classroom","author":"Aronson E","year":"1978","unstructured":"Aronson E, Blaney N, Stephan C, Sikes J, Snapp M. 1978. The jigsaw classroom. Saga, Beverly Hills, CA.."},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.3102\/0013189X09339057"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.6018\/analesps.30.3.201201"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/tea.20061"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/educsci12040276"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/07370008.2011.636495"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/jehp.jehp_111_24"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40670-021-01326-7"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/tea.21585"},{"key":"e_1_3_5_21_2","volume-title":"Cooperative learning in higher education: across the disciplines, across the academy","author":"Millis BJ","year":"2010","unstructured":"Millis BJ. 2010. Cooperative learning in higher education: across the disciplines, across the academy. Stylus Publishing, Sterling, VA."},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0000000000000731"}],"container-title":["Journal of Microbiology &amp; Biology Education"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jmbe.00111-26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jmbe.00111-26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:01:13Z","timestamp":1789131673000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jmbe.00111-26"}},"subtitle":[],"editor":[{"given":"Jeanetta H.","family":"Floyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":21,"alternative-id":["10.1128\/jmbe.00111-26"],"URL":"https:\/\/doi.org\/10.1128\/jmbe.00111-26","relation":{},"ISSN":["1935-7877","1935-7885"],"issn-type":[{"value":"1935-7877","type":"print"},{"value":"1935-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"2026-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00111-26"}}