{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:38:47Z","timestamp":1790141927942,"version":"4.0.1"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Hendra virus (HeV) is a zoonotic emerging virus belonging to the family\n            <jats:named-content content-type=\"genus-species\">Paramyxoviridae<\/jats:named-content>\n            . HeV causes severe and often fatal respiratory and\/or neurologic disease in both animals and humans. Currently, there are no licensed vaccines or antiviral drugs approved for human use. A number of animal models have been developed for studying HeV infection, with the African green monkey (AGM) appearing to most faithfully reproduce the human disease. Here, we assessed the utility of a newly developed recombinant subunit vaccine based on the HeV attachment (G) glycoprotein in the AGM model. Four AGMs were vaccinated with two doses of the HeV vaccine (sG\n            <jats:sub>HeV<\/jats:sub>\n            ) containing Alhydrogel, four AGMs received the sG\n            <jats:sub>HeV<\/jats:sub>\n            with Alhydrogel and CpG, and four control animals did not receive the sG\n            <jats:sub>HeV<\/jats:sub>\n            vaccine. Animals were challenged with a high dose of infectious HeV 21 days after the boost vaccination. None of the eight specifically vaccinated animals showed any evidence of clinical illness and survived the challenge. All four controls became severely ill with symptoms consistent with HeV infection, and three of the four animals succumbed 8 days after exposure. Success of the recombinant subunit vaccine in AGMs provides pivotal data in supporting its further preclinical development for potential human use.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>IMPORTANCE<\/jats:bold>\n            A Hendra virus attachment (G) glycoprotein subunit vaccine was tested in nonhuman primates to assess its ability to protect them from a lethal infection with Hendra virus. It was found that all vaccinated African green monkeys were completely protected against subsequent Hendra virus infection and disease. The success of this new subunit vaccine in nonhuman primates provides critical data in support of its further development for future human use.\n          <\/jats:p>","DOI":"10.1128\/jvi.00005-14","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T05:44:12Z","timestamp":1392270252000},"page":"4624-4631","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":64,"title":["A Recombinant Hendra Virus G Glycoprotein Subunit Vaccine Protects Nonhuman Primates against Hendra Virus Challenge"],"prefix":"10.1128","volume":"88","author":[{"given":"Chad E.","family":"Mire","sequence":"first","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas, USA"},{"name":"Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan B.","family":"Geisbert","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas, USA"},{"name":"Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystle N.","family":"Agans","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas, USA"},{"name":"Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ru","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla 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Guide for the care and use of laboratory animals, eighth edition. National Academies Press, Washington, DC."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010690"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2012_214"},{"key":"e_1_3_2_33_2","volume-title":"ProMED Mail archive number 20110802.2324","year":"2011","unstructured":". 2011. Hendra virus, equine\u2014Australia (21): (QL) canine. ProMED Mail archive number 20110802.2324. 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