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Human\n                    <jats:italic>Cytomegalovirus<\/jats:italic>\n                    encodes several factors that limit host countermeasures to infection, including pp71. Herein, we identified a previously unreported posttranslational modification of pp71, protein S-nitrosylation. Using site-directed mutagenesis, we mutated the specific sites of this modification thereby blocking this pp71 posttranslational modification. In contexts where pp71 is not protein S-nitrosylated, host antiviral response was inhibited. The net result of this posttranslational modification is to render a viral protein with diminished abilities to block host responses to infection. This novel work supports a model in which protein S-nitrosylation may be an additional mechanism in which a cell inhibits a pathogen during the course of infection.\n                  <\/jats:p>","DOI":"10.1128\/jvi.00033-20","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T10:29:17Z","timestamp":1592908157000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Protein S-Nitrosylation of Human Cytomegalovirus pp71 Inhibits Its Ability To Limit STING Antiviral Responses"],"prefix":"10.1128","volume":"94","author":[{"given":"Masatoshi","family":"Nukui","sequence":"first","affiliation":[{"name":"Microbiology and Immunology Department, SUNY Upstate Medical University, Syracuse, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn L.","family":"Roche","sequence":"additional","affiliation":[{"name":"Evrys Bio, Pennsylvania Biotechnology Center, Doylestown, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul L.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3449-5024","authenticated-orcid":false,"given":"Eain A.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology Department, SUNY Upstate Medical University, Syracuse, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.09.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-77349-8_23"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313.022"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/v5112803"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001273"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmz030"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2136652100"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1735466100"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vez015"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-1680-7_15"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-77-12-3087"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2334032100"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1635160100"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0538058100"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.6.3451-3459.2003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00827-07"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.05.037"},{"key":"e_1_3_2_19_2","first-page":"5049","article-title":"The COOH-terminal region of pRb2\/p130 binds to histone deacetylase 1 (HDAC1), enhancing transcriptional repression of the E2F-dependent cyclin A promoter","volume":"58","author":"Stiegler P","year":"1998","unstructured":"Stiegler P, De Luca A, Bagella L, Giordano A. 1998. 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