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The recent discovery of an HCV-like rodent hepacivirus (RHV) enabled the development of such a model in rats. This platform recapitulates HCV hepatotropism and viral chronicity necessary for vaccine testing. Currently, there are few descriptions of RHV-specific responses and why they fail to prevent persistent infection in this model. Here, we show that RHV-specific CD8 T cells, while induced early at high magnitude, do not develop into functional effectors capable of controlling virus. This defect was partially alleviated by short-term treatment with an HCV antiviral. Thus, like HCV, RHV triggers dysfunction of virus-specific CD8 T cells that are vital for infection resolution. Additional study of this evasion strategy and how to mitigate it could enhance our understanding of hepatotropic viral infections and lead to improved vaccines and therapeutics.<\/jats:p>","DOI":"10.1128\/jvi.00035-20","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T10:28:56Z","timestamp":1582712936000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Priming of Antiviral CD8 T Cells without Effector Function by a Persistently Replicating Hepatitis C-Like Virus"],"prefix":"10.1128","volume":"94","author":[{"given":"Alex S.","family":"Hartlage","sequence":"first","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"Medical Scientist Training Program, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Walker","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36227"},{"key":"e_1_3_2_3_2","volume-title":"Global hepatitis report 2017","author":"WHO","year":"2017","unstructured":"WHO. 2017. 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