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Therefore, elucidating the process of B cell infection is important for the understanding of KSHV pathogenesis. While the high-affinity receptor for the gH\/gL glycoprotein complex, EphA2, has been shown to function as an entry receptor for various types of adherent cells, the gH\/gL complex can also interact with other Eph receptor tyrosine kinases with lower avidity. We analyzed the Eph interactions required for infection of BJAB cells, a model for B cell infection by KSHV. We identified EphA7 as the principal Eph receptor for infection of BJAB cells by KSHV and the related rhesus monkey rhadinovirus. While two analyzed PEL cell lines exhibited high EphA2 and low EphA7 expression, a third PEL cell line, BCBL-1, showed high EphA7 and low EphA2 expression, indicating a possible relevance for KSHV pathology.<\/jats:p>","DOI":"10.1128\/jvi.00064-19","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T09:27:46Z","timestamp":1558517266000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["EphA7 Functions as Receptor on BJAB Cells for Cell-to-Cell Transmission of the Kaposi's Sarcoma-Associated Herpesvirus and for Cell-Free Infection by the Related Rhesus Monkey Rhadinovirus"],"prefix":"10.1128","volume":"93","author":[{"given":"Anna K.","family":"Gro\u00dfkopf","sequence":"first","affiliation":[{"name":"Junior Research Group Herpesviruses, German Primate Center\u2013Leibniz Institute for Primate Research, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Schlagowski","sequence":"additional","affiliation":[{"name":"Junior Research Group Herpesviruses, German Primate Center\u2013Leibniz Institute for Primate Research, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan F.","family":"H\u00f6rnich","sequence":"additional","affiliation":[{"name":"Junior Research Group Herpesviruses, German Primate Center\u2013Leibniz Institute for Primate Research, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fricke","sequence":"additional","affiliation":[{"name":"Junior Research Group Herpesviruses, German Primate Center\u2013Leibniz Institute for Primate Research, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6851-3003","authenticated-orcid":false,"given":"Ronald C.","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4171-2744","authenticated-orcid":false,"given":"Alexander S.","family":"Hahn","sequence":"additional","affiliation":[{"name":"Junior Research Group Herpesviruses, German Primate Center\u2013Leibniz Institute for Primate Research, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615896"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00803-18"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2805"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119592109"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006580"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003360"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.11.6474-6481.2003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200006160-00009"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01167-08"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.6.5182-5188.1998"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03063-13"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05136-11"},{"key":"e_1_3_3_14_2","first-page":"276","article-title":"Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt\u2019s lymphoma","volume":"22","author":"Menezes J","year":"1975","unstructured":"Menezes J, Leibold W, Klein G, Clements G. 1975. 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