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In virus-infected cells, RelA typically induces the expression of IFN-\u03b2, which restrains viral propagation in neighboring cells involving paracrine mechanisms. Our study suggested that RelA might also play a proviral role. A cell-autonomous RelA activity amplified the yield of Chandipura virus, a cytopathic RNA virus associated with human epidemics, by extending the life span of infected cells. Our finding necessitates a substantial revision of our understanding of host-virus interactions and indicates a dual role of NF-\u03baB signaling during the course of RNA virus infections. Our study also bears significance for therapeutic regimes which alter NF-\u03baB activities while alleviating the viral load.<\/jats:p>","DOI":"10.1128\/jvi.00081-19","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T10:23:04Z","timestamp":1556533384000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Chandipura Virus Utilizes the Prosurvival Function of RelA NF-\u03baB for Its Propagation"],"prefix":"10.1128","volume":"93","author":[{"given":"Sachendra S.","family":"Bais","sequence":"first","affiliation":[{"name":"Systems Immunology Laboratory, National Institute of Immunology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashika","family":"Ratra","sequence":"additional","affiliation":[{"name":"Systems Immunology Laboratory, National Institute of Immunology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Translational Health Sciences and Technology Institute, Faridabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Pandey","sequence":"additional","affiliation":[{"name":"Systems Immunology Laboratory, National Institute of Immunology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod K.","family":"Kushawaha","sequence":"additional","affiliation":[{"name":"Systems Immunology Laboratory, National Institute of Immunology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailly","family":"Tomar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Indian Institute of Technology, Roorkee, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-9743","authenticated-orcid":false,"given":"Guruprasad","family":"Medigeshi","sequence":"additional","affiliation":[{"name":"Translational Health Sciences and Technology Institute, Faridabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhyudai","family":"Singh","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department, University of Delaware, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-1279","authenticated-orcid":false,"given":"Soumen","family":"Basak","sequence":"additional","affiliation":[{"name":"Systems Immunology Laboratory, National Institute of Immunology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0426"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009872"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2012.06.001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10540-007-9054-z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01864-13"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00007-11"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2017.05.007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00053-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300799"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081315"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni921"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.19.10636-10649.2004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.14.7737-7747.2004"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700859"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/376167a0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000114"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12038"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","unstructured":"Bais SS Ratra Y Kushawaha PK Basak S. 2019. 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