{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:49:07Z","timestamp":1779245347924,"version":"3.51.4"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["682\/16"],"award-info":[{"award-number":["682\/16"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001658","name":"Minerva Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:p>\n            Some viruses that belong to the\n            <jats:italic>Arenaviridae<\/jats:italic>\n            family, like Lassa and Jun\u00edn viruses, are notorious human pathogens, which may lead to fatal outcomes when they infect people. It is thus important to develop means to combat these viruses. For developing effective vaccines, it is vital to understand the basic mechanisms that these viruses utilize in order to evade or overcome host immune responses. It was previously noted that the GP1 receptor-binding domain from Lassa virus is shed and accumulates in the serum of infected individuals. This raised the possibility that Lassa virus GP1 may function as an immunological decoy. Here we demonstrate that mice develop nonproductive immune responses against GP1 from Lassa virus, which is in contrast to the effective neutralizing responses that GP1 from Jun\u00edn virus elicits. Thus, GP1 from Lassa virus is indeed an immunological decoy and GP1 from Jun\u00edn virus may serve as a constituent of a future vaccine.\n          <\/jats:p>","DOI":"10.1128\/jvi.00090-19","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T10:41:56Z","timestamp":1549536116000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Differential Antibody-Based Immune Response against Isolated GP1 Receptor-Binding Domains from Lassa and Jun\u00edn Viruses"],"prefix":"10.1128","volume":"93","author":[{"given":"Aliza","family":"Borenstein-Katz","sequence":"first","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasiya","family":"Shulman","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedva","family":"Hamawi","sequence":"additional","affiliation":[{"name":"Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orith","family":"Leitner","sequence":"additional","affiliation":[{"name":"Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2837-5897","authenticated-orcid":false,"given":"Ron","family":"Diskin","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/v4010083"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.142"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1142"},{"key":"e_1_3_2_5_2","first-page":"V","article-title":"Arenaviruses. II. The molecular pathogenesis of arenavirus infections. Introduction","volume":"263","author":"Oldstone MB","year":"2002","unstructured":"Oldstone MB. 2002. Arenaviruses. II. The molecular pathogenesis of arenavirus infections. Introduction. Curr Top Microbiol Immunol 263:V\u2013XII.","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_2_6_2","first-page":"V","article-title":"Arenaviruses. I. The epidemiology molecular and cell biology of arenaviruses. Introduction","volume":"262","author":"Oldstone MB","year":"2002","unstructured":"Oldstone MB. 2002. Arenaviruses. I. The epidemiology molecular and cell biology of arenaviruses. Introduction. Curr Top Microbiol Immunol 262:V\u2013XII.","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05539"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2079"},{"key":"e_1_3_2_9_2","first-page":"111","article-title":"Receptor structure, binding, and cell entry of arenaviruses","volume":"262","author":"Kunz S","year":"2002","unstructured":"Kunz S, Borrow P, Oldstone MB. 2002. Receptor structure, binding, and cell entry of arenaviruses. Curr Top Microbiol Immunol 262:111\u2013137.","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.10.5979-5987.2005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252480"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01624-16"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/v4102162"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1456"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7260"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005418"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00651-15"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00761-09"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1772"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.11.005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.07.011"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2018.05.002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890370102"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01948-08"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000150276"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/514211"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10308"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90299-X"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11544"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2017.09.013"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005276"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1803990115"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.052"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-306"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.106"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006337"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192819"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1213782"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04271-z"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019304108"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.1.448-457.2001"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1159\/000149136"},{"key":"e_1_3_2_43_2","volume-title":"Monoclonal antibody strategy and techniques, hybridoma technology in the biosciences and medicine","author":"Eshhar Z","year":"1985","unstructured":"Eshhar Z. 1985. Monoclonal antibody strategy and techniques, hybridoma technology in the biosciences and medicine. Springer, New York, NY."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(99)00184-2"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki524"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00090-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00090-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T14:53:20Z","timestamp":1646492000000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00090-19"}},"subtitle":[],"editor":[{"given":"Rebecca Ellis","family":"Dutch","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,15]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,4,15]]}},"alternative-id":["10.1128\/JVI.00090-19"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00090-19","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,15]]},"assertion":[{"value":"2019-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00090-19"}}