{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:11:14Z","timestamp":1790619074222,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2009,5,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A bioinformatic analysis identified two putative NF-\u03baB binding sites in the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) promoter. The ability of p65RelA to interact with the LMP1 promoter was shown by in vitro and in vivo assays. Using an EBV-transformed lymphoblastoid cell line as a reporter system for the activity of the +40\/\u2212328 LMP1 promoter region, the functional importance of NF-\u03baB and other transcription factor binding sites was demonstrated. p65RelA could also induce LMP1 expression from the EBV genome in Daudi and P3HR1 Burkitt's lymphoma cell lines. Finally, it was shown that p65RelA could cooperate with EBNA2 or the aryl hydrocarbon receptor in the transactivation of the LMP1 promoter. Our study established the importance of NF-\u03baB and several\n            <jats:italic>cis<\/jats:italic>\n            -acting elements in the regulation of the LMP1 promoter in a latency III environment and highlighted a complex interplay between NF-\u03baB and other transcription factors in this process.\n          <\/jats:p>","DOI":"10.1128\/jvi.00097-09","type":"journal-article","created":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T01:45:59Z","timestamp":1236822359000},"page":"5269-5277","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["The LMP1 Promoter Can Be Transactivated Directly by NF-\u03baB"],"prefix":"10.1128","volume":"83","author":[{"given":"Constantinos","family":"Demetriades","sequence":"first","affiliation":[{"name":"School of Biology, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mosialos","sequence":"additional","affiliation":[{"name":"School of Biology, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece"},{"name":"Institute of Immunology, Biomedical Sciences Research Center Al. Fleming, 34 Al. Fleming Str., 16672 Vari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601364"},{"key":"e_1_3_2_3_2","first-page":"1487","volume":"9","year":"1994","unstructured":"Beg, A. A., and A. S. Baldwin, Jr. 1994. Activation of multiple NF-kappa B\/Rel DNA-binding complexes by tumor necrosis factor. Oncogene9:1487-1492.","journal-title":"Oncogene"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v18.i3.20"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190105"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.01.017"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.8.4108-4119.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.100119497"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.1.90"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02052-05"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-080309"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.9.6611-6618.1997"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi963145k"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82771-0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-007-0116-x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.1.253-262.1995"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01637-08"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01890.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509036200"},{"key":"e_1_3_2_20_2","first-page":"2511","year":"2001","unstructured":"Kieff, E., and A. Rickinson. 2001. Epstein-Barr virus and its replication, p. 2511-2573. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed. Lippincott, Williams & Wilkins, Philadelphia, PA.","journal-title":"Fields virology"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203945"},{"key":"e_1_3_2_22_2","first-page":"1068","year":"1967","unstructured":"Klein, E., G. Klein, J. S. Nadkarni, J. J. Nadkarni, H. Wigzell, and P. Clifford. 1967. Surgace IgM specificity on cells derived from a Burkitt's lymphoma. Lancetii:1068-1070.","journal-title":"Lancet"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000149930"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105607200"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.17.9359-9368.2003"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.18.11671-11676.2005"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.9.6619-6628.1997"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.7.4492-4505.2005"},{"key":"e_1_3_2_29_2","first-page":"2575","year":"2001","unstructured":"Rickinson, A. B., and E. Kieff. 2001. Epstein-Barr virus, p. 2575-2628. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed. Lippincott, Williams & Wilkins, Philadelphia, PA.","journal-title":"Fields virology"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.5.3068-3074.1996"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.028365"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-11-2679"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.2.1365-1376.1998"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-70630-6_14"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90136-1"},{"key":"e_1_3_2_36_2","first-page":"8293","volume":"63","year":"2003","unstructured":"Thornburg, N. J., R. Pathmanathan, and N. Raab-Traub. 2003. Activation of nuclear factor-\u03baB p50 homodimer\/Bcl-3 complexes in nasopharyngeal carcinoma. Cancer Res.63:8293-8301.","journal-title":"Cancer Res."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.12.6765-6771.1991"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0211"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.09.032"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06901.x"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00097-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00097-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:25:22Z","timestamp":1646483122000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00097-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,15]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,5,15]]}},"alternative-id":["10.1128\/JVI.00097-09"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00097-09","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,15]]},"assertion":[{"value":"2009-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}