{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:06:37Z","timestamp":1790622397163,"version":"4.1.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2008,6,15]],"date-time":"2008-06-15T00:00:00Z","timestamp":1213488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2008,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Transmission of arenaviruses from rodent hosts to humans is generally thought to occur through inhalation or ingestion of dust or droplets containing viral particles. Here we demonstrate that two identified arenavirus receptors, \u03b1-dystroglycan (\u03b1-DG) and transferrin receptor 1 (TfR1), are expressed in polarized human airway epithelia. Lymphocytic choriomeningitis virus strains with high or low \u03b1-DG affinity and Junin virus, which binds TfR1, efficiently infected polarized epithelia only when applied to the basolateral surface or when injury compromised tight junction integrity. Viral egress from infected epithelia exhibited basolateral polarity. This study demonstrates that respiratory entry of arenaviruses occurs via basolateral receptors.<\/jats:p>","DOI":"10.1128\/jvi.00100-08","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T01:10:29Z","timestamp":1208394629000},"page":"6034-6038","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Basolateral Entry and Release of New and Old World Arenaviruses from Human Airway Epithelia"],"prefix":"10.1128","volume":"82","author":[{"given":"Douglas E.","family":"Dylla","sequence":"first","affiliation":[{"name":"Genetics Ph.D. Program"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Michele","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute"},{"name":"Department of Molecular Physiology and Biophysics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Genetics Ph.D. Program"},{"name":"Howard Hughes Medical Institute"},{"name":"Department of Molecular Physiology and Biophysics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Paul B.","family":"McCray","sequence":"additional","affiliation":[{"name":"Genetics Ph.D. Program"},{"name":"Department of Pediatrics, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1642"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.13.6618-6635.2002"},{"key":"e_1_3_2_4_2","first-page":"1635","year":"2001","unstructured":"Buchmeier, M. J., M. D. Bowen, and C. J. Peters. 2001. Arenaviridae: the viruses and their replication, p. 1635-1668. In D. M. Knipe and P. M. Howley (ed.), Fields virology. 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