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In this study, we found that the expression of long noncoding RNA (lncRNA) negative regulator of antiviral response (NRAV) was reduced in RSV-infected patients, and overexpression of NRAV facilitated RSV production\n                    <jats:italic>in vitro<\/jats:italic>\n                    , suggesting that the reduction of NRAV in RSV infection was part of the host antiviral response. We also found that NRAV competed with vesicle protein Rab5c for microRNA miR509-3p in cytoplasm to promote RSV vesicle transport and accelerate RSV proliferation, thereby improving our understanding of the pathogenic mechanism of RSV infection.\n                  <\/jats:p>","DOI":"10.1128\/jvi.00113-20","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T05:29:12Z","timestamp":1582694952000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Long Noncoding RNA NRAV Promotes Respiratory Syncytial Virus Replication by Targeting the MicroRNA miR-509-3p\/Rab5c Axis To Regulate Vesicle Transportation"],"prefix":"10.1128","volume":"94","author":[{"given":"Jian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China"},{"name":"Key Laboratory of Immune Mechanism and Intervention on Serious Disease in 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