{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:46:29Z","timestamp":1791117989457,"version":"4.1.0"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"18","license":[{"start":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T00:00:00Z","timestamp":1252972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2009,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In immunocompetent individuals, the stability of the herpesvirus-host balance limits opportunities to study the disappearance of a virus-specific CD8<jats:sup>+<\/jats:sup>T-cell response. However, we noticed that in HLA-A*0201-positive infectious mononucleosis (IM) patients undergoing primary Epstein-Barr virus (EBV) infection, the initial CD8 response targets three EBV lytic antigen-derived epitopes, YVLDHLIVV (YVL), GLCTLVAML (GLC), and TLDYKPLSV (TLD), but only the YVL and GLC reactivities persist long-term; the TLD response disappears within 10 to 27 months. While present, TLD-specific cells remained largely indistinguishable from YVL and GLC reactivities in many phenotypic and functional respects but showed unique temporal changes in two markers of T-cell fate, interleukin 7 receptor alpha (IL-7R\u03b1; CD127) and programmed death 1 (PD-1). Thus, following the antigen-driven downregulation of IL-7R\u03b1 seen on all populations in acute IM, in every case, the TLD-specific population recovered expression unusually quickly post-IM. As well, in four of six patients studied, TLD-specific cells showed very strong PD-1 upregulation in the last blood sample obtained before the cells\u2019 disappearance. Our data suggest that the disappearance of this individual epitope reactivity from an otherwise stable EBV-specific response (i) reflects a selective loss of cognate antigen restimulation (rather than of IL-7-dependent signals) and (ii) is immediately preceded, and perhaps mediated, by PD-1 upregulation to unprecedented levels.<\/jats:p>","DOI":"10.1128\/jvi.00141-09","type":"journal-article","created":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T00:59:43Z","timestamp":1247705983000},"page":"9068-9078","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Upregulation of Interleukin 7 Receptor Alpha and Programmed Death 1 Marks an Epitope-Specific CD8<sup>+<\/sup>T-Cell Response That Disappears following Primary Epstein-Barr Virus Infection"],"prefix":"10.1128","volume":"83","author":[{"given":"Delphine","family":"Sauce","sequence":"first","affiliation":[{"name":"CRUK Institute for Cancer Studies and MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom"},{"name":"INSERM U543, Ho\u0302pital Pitie\u0301-Salpe\u0301trie\u0300re, Universite\u0301 Pierre et Marie Curie 6, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Larsen","sequence":"additional","affiliation":[{"name":"CRUK Institute for Cancer Studies and MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J. 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