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Our results suggest that carvacrol and thymol alter the cholesterol content of the viral membrane, blocking HIV-1 entry into the target cell. Resistance to carvacrol has selected for viruses with mutations in the viral envelope glycoprotein, gp41. This protein is known for its interaction with cholesterol present in membrane lipid rafts. Together, these results demonstrate the potential of therapies targeting the viral envelope membrane, and oregano oil is a safe supplement to antiretrovirals, potentially delaying disease progression and resistance development.<\/jats:p>","DOI":"10.1128\/jvi.00147-20","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T13:01:41Z","timestamp":1590152501000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Oregano Oil and Its Principal Component, Carvacrol, Inhibit HIV-1 Fusion into Target Cells"],"prefix":"10.1128","volume":"94","author":[{"given":"S.","family":"Mediouni","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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