{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:58:15Z","timestamp":1790470695878,"version":"4.1.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201400048C"],"award-info":[{"award-number":["HHSN272201400048C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI123535"],"award-info":[{"award-number":["1R01AI123535"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>The high morbidity and mortality associated with clinical cases of Lassa fever, together with the lack of licensed vaccines and limited and partially effective interventions, make Lassa virus (LASV) an important health concern in its regions of endemicity in West Africa. Previous infection with LASV protects from disease after subsequent exposure, providing a framework for designing vaccines to elicit similar protective immunity. Multiple major lineages of LASV circulate in West Africa, and therefore, ideal vaccine candidates should elicit immunity to all lineages. We therefore sought to identify common T cell epitopes between Lassa fever survivors from Sierra Leone and Nigeria, where distinct lineages circulate. We identified three such epitopes derived from highly conserved regions within LASV proteins. In this process, we also identified nine other T cell epitopes. These data should help in the design of an effective pan-LASV vaccine.<\/jats:p>","DOI":"10.1128\/jvi.00153-20","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T14:48:21Z","timestamp":1586184501000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Identification of Common CD8<sup>+<\/sup>T Cell Epitopes from Lassa Fever Survivors in Nigeria and Sierra Leone"],"prefix":"10.1128","volume":"94","author":[{"given":"Saori","family":"Sakabe","sequence":"first","affiliation":[{"name":"Viral Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica N.","family":"Hartnett","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhi","family":"Ngo","sequence":"additional","affiliation":[{"name":"Viral Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine","family":"Goba","sequence":"additional","affiliation":[{"name":"Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone"},{"name":"Ministry of Health and Sanitation, Freetown, Sierra Leone"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mambu","family":"Momoh","sequence":"additional","affiliation":[{"name":"Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone"},{"name":"Ministry of Health and Sanitation, Freetown, Sierra Leone"},{"name":"Eastern Polytechnic Institute, Kenema, Sierra Leone"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Demby","family":"Sandi","sequence":"additional","affiliation":[{"name":"Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone"},{"name":"Ministry of Health and Sanitation, Freetown, Sierra Leone"},{"name":"Njala University, Moyamba, Sierra Leone"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lansana","family":"Kanneh","sequence":"additional","affiliation":[{"name":"Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone"},{"name":"Ministry of Health and Sanitation, Freetown, Sierra Leone"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Cubitt","sequence":"additional","affiliation":[{"name":"Viral Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma D.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Viral Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Ware","sequence":"additional","affiliation":[{"name":"Viral Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Kotliar","sequence":"additional","affiliation":[{"name":"FAS Center for Systems Biology, Harvard University, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refugio","family":"Robles-Sikisaka","sequence":"additional","affiliation":[{"name":"Viral Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA"},{"name":"Scripps Translational Research Institute, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Gangavarapu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Branco","sequence":"additional","affiliation":[{"name":"Zalgen Labs, Germantown, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philomena","family":"Eromon","sequence":"additional","affiliation":[{"name":"African Center of Excellence for Genomics of Infectious Disease (ACEGID), Redeemers University, Ede, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikponmwosa","family":"Odia","sequence":"additional","affiliation":[{"name":"Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ephraim","family":"Ogbaini-Emovon","sequence":"additional","affiliation":[{"name":"Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onikepe","family":"Folarin","sequence":"additional","affiliation":[{"name":"African Center of Excellence for Genomics of Infectious Disease (ACEGID), Redeemers University, Ede, Nigeria"},{"name":"Department of Biological Sciences, Redeemers University, Ede, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvanus","family":"Okogbenin","sequence":"additional","affiliation":[{"name":"Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter O.","family":"Okokhere","sequence":"additional","affiliation":[{"name":"Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria"},{"name":"Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria"},{"name":"Department of Medicine, Faculty of Clinical Sciences, Ambrose Alli University, Ekpoma, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Happi","sequence":"additional","affiliation":[{"name":"African Center of Excellence for Genomics of Infectious Disease (ACEGID), Redeemers University, Ede, Nigeria"},{"name":"Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria"},{"name":"Department of Biological Sciences, Redeemers University, Ede, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardis C.","family":"Sabeti","sequence":"additional","affiliation":[{"name":"FAS Center for Systems Biology, Harvard University, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Sherlock Biosciences, Cambridge, Massachusetts, USA"},{"name":"Danaher Corporation, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian G.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Viral Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA"},{"name":"Scripps Translational Research Institute, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Garry","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA"},{"name":"Zalgen Labs, Germantown, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"de la Torre","sequence":"additional","affiliation":[{"name":"Viral Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald S.","family":"Grant","sequence":"additional","affiliation":[{"name":"Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone"},{"name":"Ministry of Health and Sanitation, Freetown, Sierra Leone"},{"name":"College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Schieffelin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B. A.","family":"Oldstone","sequence":"additional","affiliation":[{"name":"Viral Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Viral Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000836"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix201"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01948-08"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.3.456"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.1.317"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.5.2186-2192.2000"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw3163"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008352"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.020"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000388"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1212.060812"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2403.171905"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00929-19"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01037"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.15.6992-7004.2000"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806200115"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00896-06"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02239"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(97)90051-1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.1.357"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136417"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12936"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz452"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147812"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02778"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00339-13"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.4049\/jimmunol.157.12.5543","article-title":"Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection","volume":"157","author":"van der Most RG","year":"1996","unstructured":"van der Most RG, Sette A, Oseroff C, Alexander J, Murali-Krishna K, Lau LL, Southwood S, Sidney J, Chesnut RW, Matloubian M, Ahmed R. 1996. Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol 157:5543\u20135554.","journal-title":"J Immunol"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2003.07.001"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.11.5099-5107.2001"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02632-06"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.62.3.687-695.1988"},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4049\/jimmunol.136.1.304","article-title":"Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. V. Recognition is restricted to gene products encoded by the viral S RNA segment","volume":"136","author":"Riviere Y","year":"1986","unstructured":"Riviere Y, Southern PJ, Ahmed R, Oldstone MB. 1986. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. V. Recognition is restricted to gene products encoded by the viral S RNA segment. J Immunol 136:304\u2013307.","journal-title":"J Immunol"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0263-6"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.1.348-352.1993"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.166137"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102661"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141774"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1104104108"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2763"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.7890"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.30.17829"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2011.09.016"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2010.08.006"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00153-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00153-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:39:39Z","timestamp":1696001979000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00153-20"}},"subtitle":[],"editor":[{"given":"Mark T.","family":"Heise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1128\/JVI.00153-20"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00153-20","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"2020-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00153-20"}}