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We describe a recombinant strain recovered from human stools, typed as coxsackievirus B4 (CV-B4) and CV-B3 after partial sequencing of the VP1 and VP2 coding regions, respectively. The strain was neutralized by a polyclonal CV-B3-specific antiserum but not by a CV-B4-specific antiserum. The nucleotide sequence analysis of the whole structural genomic region showed the occurrence of a recombination event at position 1950 within the VP3 capsid gene, in a region coding for the 2b antigenic site previously described for CV-B3. This observation evidences for the first time the occurrence of an interserotypic recombination within the VP2-VP3-VP1 capsid region between two nonpoliovirus enterovirus strains. The neutralization pattern suggests that the major antigenic site is located within the VP2 protein.<\/jats:p>","DOI":"10.1128\/jvi.00180-07","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T00:39:15Z","timestamp":1180571955000},"page":"8944-8952","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Natural Recombination Event within the Capsid Genomic Region Leading to a Chimeric Strain of Human Enterovirus B"],"prefix":"10.1128","volume":"81","author":[{"given":"Lamjed","family":"Bouslama","sequence":"first","affiliation":[{"name":"Laboratory of Transmissible Diseases and Biologically Active Substances, Faculty of Pharmacy, Monastir, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorsaf","family":"Nasri","sequence":"additional","affiliation":[{"name":"Laboratory of Transmissible Diseases and Biologically Active Substances, Faculty of Pharmacy, Monastir, Tunisia"},{"name":"Laboratory of Bacteriology-Virology, GIMAP EA3064, Faculty of Medicine of Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Chollet","sequence":"additional","affiliation":[{"name":"Laboratory of Bacteriology-Virology, Hospital of Toulon-La Seyne sur Mer, Toulon-La Seyne sur Mer, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaoula","family":"Belguith","sequence":"additional","affiliation":[{"name":"Laboratory of Transmissible Diseases and Biologically Active Substances, Faculty of Pharmacy, Monastir, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bourlet","sequence":"additional","affiliation":[{"name":"Laboratory of Bacteriology-Virology, GIMAP EA3064, Faculty of Medicine of Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahjoub","family":"Aouni","sequence":"additional","affiliation":[{"name":"Laboratory of Transmissible Diseases and Biologically Active Substances, Faculty of Pharmacy, Monastir, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pozzetto","sequence":"additional","affiliation":[{"name":"Laboratory of Bacteriology-Virology, GIMAP EA3064, Faculty of Medicine of Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Pillet","sequence":"additional","affiliation":[{"name":"Laboratory of Bacteriology-Virology, GIMAP EA3064, Faculty of Medicine of Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00019-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1993.tb00141.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(80)90345-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18708-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-005-6909-x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-6-74"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.04.026"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.13.5740-5751.2001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(98)01263-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.1985.tb00420.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01731581"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/5.2.150"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.3.1150-1152.2006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18971-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.1.152-160.1999"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.457"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.19.10423-10431.2003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81264-0"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19469-0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.21.10921-10928.2002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(95)00048-U"},{"key":"e_1_3_2_24_2","first-page":"543","volume":"63","year":"1985","unstructured":"Melnick, J. 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