{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:00:59Z","timestamp":1791144059175,"version":"4.1.0"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T00:00:00Z","timestamp":1245024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2009,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Vaccines that elicit CD8<jats:sup>+<\/jats:sup>T-cell responses are routinely tested for immunogenicity in nonhuman primates before advancement to clinical trials. Unfortunately, the magnitude and specificity of vaccine-elicited T-cell responses are variable in currently utilized nonhuman primate populations, owing to heterogeneity in major histocompatibility (MHC) class I genetics. We recently showed that Mauritian cynomolgus macaques (MCM) have unusually simple MHC genetics, with three common haplotypes encoding a shared pair of MHC class IA alleles,<jats:italic>Mafa-A*25<\/jats:italic>and<jats:italic>Mafa-A*29<\/jats:italic>. Based on haplotype frequency, we hypothesized that CD8<jats:sup>+<\/jats:sup>T-cell responses restricted by these MHC class I alleles would be detected in nearly all MCM. We examine here the frequency and functionality of these two alleles, showing that 88% of MCM express<jats:italic>Mafa-A*25<\/jats:italic>and<jats:italic>Mafa-A*29<\/jats:italic>and that animals carrying these alleles mount three newly defined simian immunodeficiency virus-specific CD8<jats:sup>+<\/jats:sup>T-cell responses. The epitopes recognized by each of these responses accumulated substitutions consistent with immunologic escape, suggesting these responses exert antiviral selective pressure. The demonstration that<jats:italic>Mafa-A*25<\/jats:italic>and<jats:italic>Mafa-A*29<\/jats:italic>restrict CD8<jats:sup>+<\/jats:sup>T-cell responses that are shared among nearly all MCM indicates that these animals are an advantageous nonhuman primate model for comparing the immunogenicity of vaccines that elicit CD8<jats:sup>+<\/jats:sup>T-cell responses.<\/jats:p>","DOI":"10.1128\/jvi.00199-09","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T00:45:19Z","timestamp":1238633119000},"page":"6011-6019","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":70,"title":["Mauritian Cynomolgus Macaques Share Two Exceptionally Common Major Histocompatibility Complex Class I Alleles That Restrict Simian Immunodeficiency Virus-Specific CD8<sup>+<\/sup>T Cells"],"prefix":"10.1128","volume":"83","author":[{"given":"Benjamin J.","family":"Burwitz","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad J.","family":"Pendley","sequence":"additional","affiliation":[{"name":"Wisconsin National Primate Research Center, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Greene","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Detmer","sequence":"additional","affiliation":[{"name":"Wisconsin National Primate Research Center, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Lhost","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Karl","sequence":"additional","affiliation":[{"name":"Wisconsin National Primate Research Center, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari M.","family":"Piaskowski","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Rudersdorf","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle T.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin N.","family":"Bimber","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Loffredo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl G.","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Bardet","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger W.","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Wisconsin National Primate Research Center, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby L.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706"},{"name":"Wisconsin National Primate Research Center, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(99)01592-6"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.2.738-749.2001"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.4049\/jimmunol.160.12.6062","volume":"160","year":"1998","unstructured":"Allen, T. M., J. Sidney, M. F. del Guercio, R. L. Glickman, G. L. Lensmeyer, D. A. Wiebe, R. DeMars, C. D. Pauza, R. P. Johnson, A. Sette, and D. I. Watkins. 1998. Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A*01) that binds an immunodominant CTL epitope from simian immunodeficiency virus. J. Immunol.160:6062-6071.","journal-title":"J. Immunol."},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.2008\/001693-0"},{"key":"e_1_3_1_6_2","unstructured":"The monkey wars. 1995"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.9.6103-6110.1994"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61591-3"},{"key":"e_1_3_1_9_2","first-page":"177","volume":"61","year":"2008","unstructured":"Campbell, K. J., A. M. Detmer, J. A. Karl, R. W. Wiseman, A. J. Blasky, A. L. Hughes, B. N. Bimber, S. L. O'Connor, and D. H. O'Connor. 2008. Characterization of 47 MHC class I sequences in Filipino cynomolgus macaques. Immunogenetics61:177-187.","journal-title":"Immunogenetics"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.14.6501-6510.2000"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.2307\/3283652"},{"key":"e_1_3_1_12_2","first-page":"501","volume":"1987","year":"1987","unstructured":"Daniel, M. D., R. C. Desrosiers, N. L. Letvin, N. W. King, D. K. Schmidt, P. Sehgal, and R. D. Hunt. 1987. Simian models for AIDS. Cancer Detect Prev.1987(Suppl. 1):501-507.","journal-title":"Cancer Detect Prev."},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.03.100"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02392-06"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/358495a0"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01816-07"},{"key":"e_1_3_1_17_2","unstructured":"Mosquitoes malaria and man: a history of the hostilities since 1880. 1978"},{"key":"e_1_3_1_18_2","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.4049\/jimmunol.162.11.6942","volume":"162","year":"1999","unstructured":"Hendel, H., S. Caillat-Zucman, H. Lebuanec, M. Carrington, S. O'Brien, J. M. Andrieu, F. Schachter, D. Zagury, J. Rappaport, C. Winkler, G. W. Nelson, and J. F. Zagury. 1999. New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS. J. Immunol.162:6942-6946.","journal-title":"J. Immunol."},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(00)00216-0"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0496-405"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/331619a0"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.7.4650-4655.1994"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5230"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330960203"},{"key":"e_1_3_1_25_2","first-page":"29","year":"2007","unstructured":"Loffredo, J. T., L. E. Valentine, and D. I. Watkins. 2007. Beyond Mamu-A*01+ Indian rhesus macaques: continued discovery of new MHC class I molecules that bind epitopes from the simian AIDS viruses, p. 29-51 In B. T. Korber, C. Brander, B. F. Haynes, R. Koup, J. P. Moore, B. D. Walker, and D. I. Watkins (ed.), HIV molecular immunology 2006\/2007. Los Alamos National Laboratory, Los Alamos, NM.","journal-title":"HIV molecular immunology 2006\/2007."},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01912-06"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00895-07"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.1.164-169.1998"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61592-5"},{"key":"e_1_3_1_30_2","first-page":"1","volume":"38","year":"2008","unstructured":"Mee, E. T., A. Badhan, J. A. Karl, R. W. Wiseman, K. Cutler, L. A. Knapp, N. Almond, D. H. O'Connor, and N. J. Rose. 2008. MHC haplotype frequencies in a UK breeding colony of Mauritian cynomolgus macaques mirror those found in a distinct population from the same geographic origin. J. Med. Primatol38:1-14.","journal-title":"J. Med. Primatol"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.11.1921"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.6.3438"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81934-0"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-008-0292-4"},{"key":"e_1_3_1_35_2","unstructured":"MHC ligands and peptide motifs. 1998"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-008-0330-2"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.14.8878-8885.2005"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg070"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.13.8131-8141.2005"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072681"},{"key":"e_1_3_1_41_2","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.4049\/jimmunol.142.9.3320","volume":"142","year":"1989","unstructured":"Shimizu, Y., and R. DeMars. 1989. Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line. J. Immunol.142:3320-3328.","journal-title":"J. Immunol."},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.6.4.1074-1087.1986"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6387"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0708117"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0684.2001.d01-54.x"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2006.08.002"},{"key":"e_1_3_1_47_2","first-page":"155","volume":"56","year":"2004","unstructured":"Uda, A., K. Tanabayashi, Y. K. Yamada, H. Akari, Y. J. Lee, R. Mukai, K. Terao, and A. Yamada. 2004. Detection of 14 alleles derived from the MHC class I A locus in cynomolgus monkeys. Immunogenetics56:155-163.","journal-title":"Immunogenetics"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.22.11623-11636.2002"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01841-06"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.10.5074-5077.2006"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.3.1707-1711.1993"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00199-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00199-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T08:51:17Z","timestamp":1710233477000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00199-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,15]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,6,15]]}},"alternative-id":["10.1128\/JVI.00199-09"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00199-09","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,15]]},"assertion":[{"value":"2009-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}