{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:20:47Z","timestamp":1790518847747,"version":"4.1.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T00:00:00Z","timestamp":1337040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2012,5,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Tacaribe virus (TCRV) was first isolated from 11\n            <jats:named-content content-type=\"genus-species\">Artibeus<\/jats:named-content>\n            species bats captured in Trinidad in the 1950s during a rabies virus surveillance program. Despite significant effort, no evidence of infection of other mammals, mostly rodents, was found, suggesting that no other vertebrates harbored TCRV. For this reason, it was hypothesized that TCRV was naturally hosted by artibeus bats. This is in stark contrast to other arenaviruses with known hosts, all of which are rodents. To examine this hypothesis, we conducted experimental infections of Jamaican fruit bats (\n            <jats:named-content content-type=\"genus-species\">Artibeus jamaicensis<\/jats:named-content>\n            ) to determine whether they could be persistently infected without substantial pathology. We subcutaneously or intranasally infected bats with TCRV strain TRVL-11573, the only remaining strain of TCRV, and found that low-dose (10\n            <jats:sup>4<\/jats:sup>\n            50% tissue culture infective dose [TCID\n            <jats:sub>50<\/jats:sub>\n            ]) inoculations resulted in asymptomatic and apathogenic infection and virus clearance, while high-dose (10\n            <jats:sup>6<\/jats:sup>\n            TCID\n            <jats:sub>50<\/jats:sub>\n            ) inoculations caused substantial morbidity and mortality as early as 10 days postinfection. Uninoculated cage mates failed to seroconvert, and viral RNA was not detected in their tissues, suggesting that transmission did not occur. Together, these data suggest that\n            <jats:named-content content-type=\"genus-species\">A. jamaicensis<\/jats:named-content>\n            bats may not be a reservoir host for TCRV.\n          <\/jats:p>","DOI":"10.1128\/jvi.00201-12","type":"journal-article","created":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T02:41:17Z","timestamp":1330569677000},"page":"5791-5799","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":91,"title":["Tacaribe Virus Causes Fatal Infection of An Ostensible Reservoir Host, the Jamaican Fruit Bat"],"prefix":"10.1128","volume":"86","author":[{"given":"Ann","family":"Cogswell-Hawkinson","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Northern Colorado, Greeley, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"James","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Northern Colorado, Greeley, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Calisher","sequence":"additional","affiliation":[{"name":"Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Adams","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Northern Colorado, Greeley, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Schountz","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Northern Colorado, Greeley, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"465","article-title":"Tacaribe virus infection of the mouse: an immunopathologic disease model","volume":"30","author":"Borden EC","year":"1974","unstructured":"BordenEC NathansonN. 1974. Tacaribe virus infection of the mouse: an immunopathologic disease model. Lab. Invest. 30:465\u2013473.","journal-title":"Lab. 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Mitochondrial DNA polymorphism in three Antillean island populations of the fruit bat, Artibeus jamaicensis. Mol. Biol. Evol. 5:79\u201389.","journal-title":"Mol. Biol. Evol."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2516(96)89650-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2010.06.020"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.50.452"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000536"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-31.1.1"},{"key":"e_1_3_2_28_2","first-page":"493","article-title":"Infection of wild and laboratory animals with Machupo and Latino viruses","volume":"52","author":"Webb PA","year":"1975","unstructured":"WebbPA JustinesG JohnsonKM. 1975. Infection of wild and laboratory animals with Machupo and Latino viruses. Bull. World Health Organ. 52:493\u2013499.","journal-title":"Bull. 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