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The reduced proliferation in cells expressing type 2 EBNA2 correlated with loss of expression of some cell genes that are known to be targets of type 1 EBNA2. Microarray analysis of EBNA2 target genes identified a small number of genes that are more strongly induced by type 1 than by type 2 EBNA2, and one of these genes (CXCR7) was shown to be required for proliferation of lymphoblastoid cell lines. The Epstein-Barr virus LMP1 gene was also more strongly induced by type 1 EBNA2 than by type 2, but this effect was transient. Type 1 and type 2 EBNA2 were equally effective at arresting cell proliferation of Burkitt's lymphoma cell lines lacking Epstein-Barr virus and were also shown to cause apoptosis in these cells. The results indicate that differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2 may be the basis for the much weaker B-cell transformation activity of type 2 Epstein-Barr virus strains compared to type 1 strains.<\/jats:p>","DOI":"10.1128\/jvi.00223-08","type":"journal-article","created":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T01:39:34Z","timestamp":1210815574000},"page":"7456-7466","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["Differential Gene Regulation by Epstein-Barr Virus Type 1 and Type 2 EBNA2"],"prefix":"10.1128","volume":"82","author":[{"given":"Walter","family":"Lucchesi","sequence":"first","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Brady","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Dittrich-Breiholz","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Medical School Hannover, Carl-Neuberg Strasse 1, D-30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kracht","sequence":"additional","affiliation":[{"name":"Rudolf-Buchheim-Institut fu\u0308r Pharmakologie, Frankfurter Strasse 107, D-35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Russ","sequence":"additional","affiliation":[{"name":"Genedata AG, Maulbeerstrasse 46, CH-4058 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90546-O"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.24.13460-13469.2004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/310207a0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508234200"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-002-0430-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.4.2209-2220.1993"},{"key":"e_1_3_2_8_2","first-page":"1397","volume":"60","year":"2007","unstructured":"Brady, G., G. 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