{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:01:35Z","timestamp":1792598495710,"version":"4.5.0"},"reference-count":79,"publisher":"American Society for Microbiology","issue":"14","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["CA136367"],"award-info":[{"award-number":["CA136367"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["GM120358"],"award-info":[{"award-number":["GM120358"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI122528"],"award-info":[{"award-number":["AI122528"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI147183"],"award-info":[{"award-number":["AI147183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["131370-PF-17-245-01-MPC"],"award-info":[{"award-number":["131370-PF-17-245-01-MPC"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE 1752814"],"award-info":[{"award-number":["DGE 1752814"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Viral infection dramatically changes the levels of many types of RNA in a cell. In particular, certain oncogenic viruses activate expression of repetitive genes called retrotransposons, which are normally silenced due to their ability to copy and spread throughout the genome. Here, we established that infection with the gammaherpesvirus MHV68 leads to a dramatic induction of a class of noncoding retrotransposons called B2 SINEs in multiple cell types. We then explored how MHV68 activates B2 SINEs, revealing a role for the conserved herpesviral protein kinase ORF36. Both ORF36 kinase-dependent and kinase-independent functions contribute to B2 induction, perhaps through ORF36 targeting of proteins involved in controlling the accessibility of chromatin surrounding SINE loci. Understanding the features underlying induction of these elements following MHV68 infection should provide insight into core elements of SINE regulation, as well as disregulation of SINE elements associated with disease.<\/jats:p>","DOI":"10.1128\/jvi.00262-20","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T10:47:46Z","timestamp":1589280466000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Conserved Herpesvirus Kinase ORF36 Activates B2 Retrotransposons during Murine Gammaherpesvirus Infection"],"prefix":"10.1128","volume":"94","author":[{"given":"Aaron M.","family":"Schaller","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Plant &amp; Microbial Biology, University of California Berkeley, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Willis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA"},{"name":"Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt A.","family":"Glaunsinger","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA"},{"name":"Department of Plant &amp; Microbial Biology, University of California Berkeley, Berkeley, California, USA"},{"name":"Howard Hughes Medical Institute, Berkeley, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/hdy.2011.43"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.91"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35057062"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2640"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.03.011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0501-77"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7247"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1018902"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-062917-012624"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00319-10"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7569"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.6.1087"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.10.1758"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.12.013"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb813"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/314553a0"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.06.040"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)81667-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1995.0239"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1357"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005260"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx180"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-017-0005-y"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07314-7"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001001"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09830"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.036"},{"key":"e_1_3_2_29_2","first-page":"2187","article-title":"Enhanced Alu RNA stability due to iron-mediated DICER1 impairment causes NLRP3 inflammasome priming","volume":"55","author":"Wright CB","year":"2014","unstructured":"Wright CB, Kim Y, Yasuma T, Li S, Fowler BJ, Kleinman ME, Ambati J, Gelfand BD. 2014. Enhanced Alu RNA stability due to iron-mediated DICER1 impairment causes NLRP3 inflammasome priming. Invest Ophthalmol Vis Sci 55:2187\u20132187. https:\/\/arvojournals.org\/article.aspx?articleid=2267504.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1403814111"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220887"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.369"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.310307"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02713-12"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03278-13"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020890"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01167-08"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.70.9.6516-6518.1996"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02689-07"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens6010009"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.08.019"},{"key":"e_1_3_2_42_2","first-page":"289","article-title":"Identification and characterisation of the porcine 7SK RNA polymerase III promoter for short hairpin RNA expression","volume":"4","author":"Cummins D","year":"2008","unstructured":"Cummins D, Doran TJ, Tyack S, Purcell D, Hammond J. 2008. Identification and characterisation of the porcine 7SK RNA polymerase III promoter for short hairpin RNA expression. J RNAi Gene Silencing 4:289\u2013294.","journal-title":"J RNAi Gene Silencing"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2012.11.004"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.258350.115"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10030085"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01173-18"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00823-18"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2937"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00999-10"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300799"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002297"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18639-0"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.19.10488-10503.2003"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm060696s"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.05.008"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.12.013"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001092"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01369-10"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304072200"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.123679.111"},{"key":"e_1_3_2_61_2","doi-asserted-by":"crossref","unstructured":"Vabret N Najburg V Solovyov A \u0160ulc P Balan S. 2019. Y-RNAs lead an endogenous program of RIG-I agonism mobilized upon RNA virus infection and targeted by HIV. bioRxiv https:\/\/www.biorxiv.org\/content\/10.1101\/773820v1.","DOI":"10.1101\/773820"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.438"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013742"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00638-14"},{"key":"e_1_3_2_65_2","unstructured":"Bonhoure N Praz V Moir RD Willemin G Mange F. 2019. Chronic repression by MAF1 supports futile RNA cycling as a mechanism for obesity resistance. BioRxiv https:\/\/www.biorxiv.org\/content\/10.1101\/775353v1."},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005346"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M900956200"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.2.475"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11770-0"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18050974"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.3390\/v9060131"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24179"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2858"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97053"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600587113"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.8.5894-5904.1997"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.05.086"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.012"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8009221"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901033"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00262-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00262-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T09:57:04Z","timestamp":1646474224000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00262-20"}},"subtitle":[],"editor":[{"given":"Rozanne M.","family":"Sandri-Goldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":79,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1128\/JVI.00262-20"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00262-20","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.01.06.895789","asserted-by":"object"}]},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2020-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00262-20"}}