{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:15:59Z","timestamp":1790201759194,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"13","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n                    In Africa, Epstein-Barr virus infection is associated with endemic Burkitt lymphoma, a pediatric cancer. The molecular events leading to its development are poorly understood compared with those leading to sporadic Burkitt lymphoma. In a previous study, by analyzing the DNA methylation changes in endemic compared with sporadic Burkitt lymphoma cell lines, we identified several differential methylated genomic positions in the proximity of genes with a potential role in cancer, and among them was the\n                    <jats:italic>KDM2B<\/jats:italic>\n                    gene.\n                    <jats:italic>KDM2B<\/jats:italic>\n                    encodes a histone H3 demethylase already shown to be involved in some hematological disorders. However, whether KDM2B plays a role in the development of Epstein-Barr virus-mediated lymphoma has not been investigated before. In this study, we show that Epstein-Barr virus deregulates KDM2B expression and describe the underlying mechanisms. We also reveal a role of the demethylase in controlling viral and B-cell gene expression, thus highlighting a novel interaction between the virus and the cellular epigenome.\n                  <\/jats:p>","DOI":"10.1128\/jvi.00273-19","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T07:02:46Z","timestamp":1555484566000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection"],"prefix":"10.1128","volume":"93","author":[{"given":"Romina C.","family":"Vargas-Ayala","sequence":"first","affiliation":[{"name":"International Agency for Research on Cancer, World Health Organization, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonin","family":"Jay","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer, 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