{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:12Z","timestamp":1792787232766,"version":"4.5.0"},"reference-count":110,"publisher":"American Society for Microbiology","issue":"14","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Military Infectious Disease Research Program","award":["Area T"],"award-info":[{"award-number":["Area T"]}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["RO1AI098933"],"award-info":[{"award-number":["RO1AI098933"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2016,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Andes virus (ANDV) is associated with a lethal vascular leak syndrome in humans termed hantavirus pulmonary syndrome (HPS). The mechanism for the massive vascular leakage associated with HPS is poorly understood; however, dysregulation of components of the immune response is often suggested as a possible cause. Alveolar macrophages are found in the alveoli of the lung and represent the first line of defense to many airborne pathogens. To determine whether alveolar macrophages play a role in HPS pathogenesis, alveolar macrophages were depleted in an adult rodent model of HPS that closely resembles human HPS. Syrian hamsters were treated, intratracheally, with clodronate-encapsulated liposomes or control liposomes and were then challenged with ANDV. Treatment with clodronate-encapsulated liposomes resulted in significant reduction in alveolar macrophages, but depletion did not prevent pathogenesis or prolong disease. Depletion also did not significantly reduce the amount of virus in the lung of ANDV-infected hamsters but altered neutrophil recruitment, MIP-1\u03b1 and MIP-2 chemokine expression, and vascular endothelial growth factor (VEGF) levels in hamster bronchoalveolar lavage (BAL) fluid early after intranasal challenge. These data demonstrate that alveolar macrophages may play a limited protective role early after exposure to aerosolized ANDV but do not directly contribute to hantavirus disease pathogenesis in the hamster model of HPS.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>IMPORTANCE<\/jats:bold>\n                    Hantaviruses continue to cause disease worldwide for which there are no FDA-licensed vaccines, effective postexposure prophylactics, or therapeutics. Much of this can be attributed to a poor understanding of the mechanism of hantavirus disease pathogenesis. Hantavirus disease has long been considered an immune-mediated disease; however, by directly manipulating the Syrian hamster model, we continue to eliminate individual immune cell types. As the most numerous immune cells present in the respiratory tract, alveolar macrophages are poised to defend against hantavirus infection, but those antiviral responses may also contribute to hantavirus disease. Here, we demonstrate that, like in our prior T and B cell studies, alveolar macrophages neither prevent hantavirus infection nor cause hantavirus disease. While these studies reflect pathogenesis in the hamster model, they should help us rule out specific cell types and prompt us to consider other potential mechanisms of disease in an effort to improve the outcome of human HPS.\n                  <\/jats:p>","DOI":"10.1128\/jvi.00304-16","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T01:43:51Z","timestamp":1461203031000},"page":"6200-6215","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Depletion of Alveolar Macrophages Does Not Prevent Hantavirus Disease Pathogenesis in Golden Syrian Hamsters"],"prefix":"10.1128","volume":"90","author":[{"given":"Christopher D.","family":"Hammerbeck","sequence":"first","affiliation":[{"name":"Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Ft. Detrick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Brocato","sequence":"additional","affiliation":[{"name":"Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Ft. Detrick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Bell","sequence":"additional","affiliation":[{"name":"Pathology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Ft. Detrick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Schellhase","sequence":"additional","affiliation":[{"name":"Pathology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Ft. Detrick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Mraz","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Ft. Detrick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie A.","family":"Queen","sequence":"additional","affiliation":[{"name":"Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Ft. Detrick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay W.","family":"Hooper","sequence":"additional","affiliation":[{"name":"Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Ft. Detrick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0302.970202"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.50.1.531"},{"key":"e_1_3_2_4_2","first-page":"43","article-title":"Hantaviruses: a tale of two hemispheres","volume":"45","author":"Khan A","year":"2003","unstructured":"Khan A, Khan AS. 2003. Hantaviruses: a tale of two hemispheres. Panminerva Med 45:43\u201351.","journal-title":"Panminerva Med"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.10.012"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01822-07"},{"key":"e_1_3_2_7_2","first-page":"171","article-title":"Vaccines against hantaviruses","volume":"256","author":"Hooper JW","year":"2001","unstructured":"Hooper JW, Li D. 2001. Vaccines against hantaviruses. Curr Top Microbiol Immunol 256:171\u2013191.","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_2_8_2","first-page":"1581","volume-title":"Fields virology","author":"Schmaljohn CS","year":"2001","unstructured":"Schmaljohn CS, Hooper JW. 2001. Bunyaviridae: the viruses and their replication, p 1581\u20131602. In Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (ed), Fields virology, 4th ed. Lippincott, Williams, and Wilkins, Philadelphia, PA.","edition":"4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/23812"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03114.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S83493"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.27"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02602-07"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.23.14933-14944.2005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90201.2008"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.08.019"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(03)00105-7"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.43.1.24"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.08.006"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05901.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.06.033"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.01902.x"},{"key":"e_1_3_2_23_2","first-page":"710","article-title":"IL-6 increases endothelial permeability in vitro","volume":"131","author":"Maruo N","year":"1992","unstructured":"Maruo N, Morita I, Shirao M, Murota S. 1992. IL-6 increases endothelial permeability in vitro. Endocrinology 131:710\u2013714.","journal-title":"Endocrinology"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03074.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/314597"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.1.38"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01233-12"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.24.11966-11971.2000"},{"key":"e_1_3_2_29_2","first-page":"552","article-title":"Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease","volume":"146","author":"Zaki SR","year":"1995","unstructured":"Zaki SR, Greer PW, Coffield LM, Goldsmith CS, Nolte KB, Foucar K, Feddersen RM, Zumwalt RE, Miller GL, Khan AS, Rollin PR, Ksiazek TG, Nichol ST, Mahy BWJ, Peters CJ. 1995. Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease. Am J Pathol 146:552\u2013579.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1885-x"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1133"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.8.3029-3035.2000"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.9.1497"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00238-07"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200409-1202OC"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200308-1107OC"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111630"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2236"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.01.033"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1086\/593173"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02541-07"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2010.0143"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004053"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0414OC"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.7.3164-3169.1998"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200660"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)00390-8"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01559-09"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01891-14"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090720"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131092"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0025OC"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808643200"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1730"},{"key":"e_1_3_2_55_2","first-page":"19","article-title":"Viral replication and host gene expression in alveolar macrophages infected with Ebola virus (Zaire strain)","volume":"9","author":"Gibb TR","year":"2002","unstructured":"Gibb TR, Norwood DA Jr, Woollen N, Henchal EA. 2002. Viral replication and host gene expression in alveolar macrophages infected with Ebola virus (Zaire strain). Clin Diagn Lab Immunol 9:19\u201327.","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762007000200009"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083386"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002426"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3600"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.2.499"},{"key":"e_1_3_2_61_2","first-page":"266","article-title":"Regulation of T-cell function in lung tissue by pulmonary alveolar macrophages","volume":"80","author":"Strickland DH","year":"1993","unstructured":"Strickland DH, Thepen T, Kees UR, Kraal G, Holt PG. 1993. Regulation of T-cell function in lung tissue by pulmonary alveolar macrophages. Immunology 80:266\u2013272.","journal-title":"Immunology"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.2.397"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287390500196081"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.103001.114744"},{"key":"e_1_3_2_65_2","first-page":"231","article-title":"Cytokine modulation of the immunosuppressive phenotype of pulmonary alveolar macrophage populations","volume":"86","author":"Bilyk N","year":"1995","unstructured":"Bilyk N, Holt PG. 1995. Cytokine modulation of the immunosuppressive phenotype of pulmonary alveolar macrophage populations. Immunology 86:231\u2013237.","journal-title":"Immunology"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00453.2001"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66142"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.4.1139-1146.1997"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.8.4585-4592.2000"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000163"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.10.007"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1080\/019021490944223"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.06.008"},{"key":"e_1_3_2_74_2","first-page":"L819","article-title":"Depletion of alveolar macrophages decreases neutrophil chemotaxis to Pseudomonas airspace infections","volume":"270","author":"Hashimoto S","year":"1996","unstructured":"Hashimoto S, Pittet JF, Hong K, Folkesson H, Bagby G, Kobzik L, Frevert C, Watanabe K, Tsurufuji S, Wiener-Kronish J. 1996. Depletion of alveolar macrophages decreases neutrophil chemotaxis to Pseudomonas airspace infections. Am J Physiol 270:L819\u2013L828.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1081\/LPR-120014760"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00086.2006"},{"key":"e_1_3_2_77_2","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.4049\/jimmunol.147.12.4307","article-title":"Cytokine (tumor necrosis factor, IL-6, and IL-8) production by respiratory syncytial virus-infected human alveolar macrophages","volume":"147","author":"Becker S","year":"1991","unstructured":"Becker S, Quay J, Soukup J. 1991. Cytokine (tumor necrosis factor, IL-6, and IL-8) production by respiratory syncytial virus-infected human alveolar macrophages. J Immunol 147:4307\u20134312.","journal-title":"J Immunol"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00233.2002"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.13.6070-6085.2001"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192298899"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00432"},{"key":"e_1_3_2_82_2","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.4049\/jimmunol.141.10.3383","article-title":"Effects of granulocyte-macrophage colony-stimulating factor and colony-stimulating factor-1 on the proliferation and differentiation of murine alveolar macrophages","volume":"141","author":"Akagawa KS","year":"1988","unstructured":"Akagawa KS, Kamoshita K, Tokunaga T. 1988. Effects of granulocyte-macrophage colony-stimulating factor and colony-stimulating factor-1 on the proliferation and differentiation of murine alveolar macrophages. J Immunol 141:3383\u20133390.","journal-title":"J Immunol"},{"key":"e_1_3_2_83_2","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.4049\/jimmunol.147.4.1266","article-title":"Granulocyte-macrophage colony-stimulating factor promotes the proliferation of human alveolar macrophages in vitro","volume":"147","author":"Nakata K","year":"1991","unstructured":"Nakata K, Akagawa KS, Fukayama M, Hayashi Y, Kadokura M, Tokunaga T. 1991. Granulocyte-macrophage colony-stimulating factor promotes the proliferation of human alveolar macrophages in vitro. J Immunol 147:1266\u20131272.","journal-title":"J Immunol"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00035-08"},{"key":"e_1_3_2_85_2","first-page":"115","article-title":"Hantavirus epidemic in Europe, 1993","volume":"343","author":"Rollin PE","year":"1994","unstructured":"Rollin PE, Coudrier D, Sureau P. 1994. Hantavirus epidemic in Europe, 1993. Lancet 343:115\u2013116.","journal-title":"Lancet"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00774-6"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-457"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02397-07"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00576-10"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01405-10"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-012-1245-7"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/674360"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1177\/030006051204000519"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-27"},{"key":"e_1_3_2_95_2","first-page":"4539","article-title":"Immunohistochemical expression of MPO, CD163 and VEGF in inflammatory cells in acute respiratory distress syndrome: a case report","volume":"7","author":"Maretta M","year":"2014","unstructured":"Maretta M, Toth S, Jonecova Z, Kruzliak P, Kubatka P, Pingorova S, Vesela J. 2014. Immunohistochemical expression of MPO, CD163 and VEGF in inflammatory cells in acute respiratory distress syndrome: a case report. Int J Clin Exp Pathol 7:4539\u20134544.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2012.02693.x"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.00863.x"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2010.01202.x"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.01.016"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14c11.x"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00089802"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-466532"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.62.3.397"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00464.2001"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00254-14"},{"key":"e_1_3_2_106_2","first-page":"15","article-title":"Neutrophil diapedesis: paracellular or transcellular?","volume":"16","author":"Kvietys PR","year":"2001","unstructured":"Kvietys PR, Sandig M. 2001. Neutrophil diapedesis: paracellular or transcellular? News Physiol Sci 16:15\u201319.","journal-title":"News Physiol Sci"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00011.2011"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10493"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(88)90048-9"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05356-11"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12116"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00304-16","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00304-16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T17:55:46Z","timestamp":1718474146000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00304-16"}},"subtitle":[],"editor":[{"given":"S.","family":"Perlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,15]]},"references-count":110,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2016,7,15]]}},"alternative-id":["10.1128\/JVI.00304-16"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00304-16","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,15]]},"assertion":[{"value":"2016-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}