{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:00:53Z","timestamp":1791874853977,"version":"4.3.4"},"reference-count":65,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Tenovus Scotland","award":["T15\/38"],"award-info":[{"award-number":["T15\/38"]}]},{"name":"Sino-Africa Joint Research Centre","award":["SAJC201605"],"award-info":[{"award-number":["SAJC201605"]}]},{"name":"Wellcome Trust Institutional Strategic Support Fund","award":["MR\/P022146\/1"],"award-info":[{"award-number":["MR\/P022146\/1"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PA 815\/2-1"],"award-info":[{"award-number":["PA 815\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2015CB755600"],"award-info":[{"award-number":["2015CB755600"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012326","name":"University of Idaho","doi-asserted-by":"publisher","award":["YDP-764"],"award-info":[{"award-number":["YDP-764"]}],"id":[{"id":"10.13039\/100012326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81620108021"],"award-info":[{"award-number":["81620108021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31170155"],"award-info":[{"award-number":["31170155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81427801"],"award-info":[{"award-number":["81427801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Human cytomegalovirus (HCMV) infections are a leading cause of brain damage, hearing loss, and other neurological disabilities in children. We report that the HCMV proteins known as IE1 and IE2 target expression of human SOX2, a central pluripotency-associated transcription factor that governs neural progenitor cell (NPC) fate and is required for normal brain development. Both during HCMV infection and when expressed alone, IE1 causes the loss of SOX2 from NPCs. IE1 mediates SOX2 depletion by targeting STAT3, a critical upstream regulator of SOX2 expression. Our findings reveal an unanticipated mechanism by which a common virus may cause damage to the developing nervous system and suggest novel targets for medical intervention.<\/jats:p>","DOI":"10.1128\/jvi.00340-18","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T09:32:38Z","timestamp":1529919158000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus"],"prefix":"10.1128","volume":"92","author":[{"given":"Cong-Cong","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Virology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Wuhan, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Zhang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Wuhan, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Qing","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Harwardt","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Min","family":"Xia","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"The Third Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Britt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama School of Medicine, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Paulus","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany"},{"name":"Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7115-407X","authenticated-orcid":false,"given":"Michael","family":"Nevels","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hua","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Wuhan, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"},{"name":"Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050150092023"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380140074025"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53488-0.00015-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.77.6.801"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.66.5.758"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318198c724"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-004-2552-y"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025023131029"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.08.018"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199202000-00007"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1055\/s-0042-1748054","article-title":"Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus","volume":"11","author":"Dahle AJ","year":"2000","unstructured":"Dahle AJ, Fowler KB, Wright JD, Boppana SB, Britt WJ, Pass RF. 2000. Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus. J Am Acad Audiol 11:283\u2013290.","journal-title":"J Am Acad Audiol"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.475"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20682"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02161-09"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00943-08"},{"key":"e_1_3_2_17_2","first-page":"215","article-title":"Human cytomegalovirus causes productive infection and neuronal injury in differentiating fetal human central nervous system neuroepithelial precursor cells","volume":"3","author":"McCarthy M","year":"2000","unstructured":"McCarthy M, Auger D, Whittemore SR. 2000. Human cytomegalovirus causes productive infection and neuronal injury in differentiating fetal human central nervous system neuroepithelial precursor cells. J Hum Virol 3:215\u2013228.","journal-title":"J Hum Virol"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00676-06"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21144"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01120-13"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.181487.111"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2005.00158.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1120"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30642"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32384"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.05.018"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103113108"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121003109"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.46582\/jsrm.0803009"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1352"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0951"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1589"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(00)00018-3"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5337.477"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00224-0"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2007.0098"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3150-12.2013"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052710599"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.4.1870-1878.2001"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01197-13"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005748"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.27080"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01912"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.04.019"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2575"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.117598"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2015.00047"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.02.008"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2014.00015"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.06.018"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.23.12135-12148.2002"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1159\/000150507"},{"key":"e_1_3_2_55_2","volume-title":"Human herpesviruses: biology, therapy, and immunoprophylaxis","author":"Stinski MF","year":"2007","unstructured":"Stinski MF, Meier JL. 2007. Immediate-early viral gene regulation and function, Chapter 17. In Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K (ed), Human herpesviruses: biology, therapy, and immunoprophylaxis. Cambridge University Press, Cambridge, UK."},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2015-3065"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.91"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01740-14"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10854"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002016"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088531"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006542"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.853"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.37"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gms041"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01670-06"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00340-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00340-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T04:51:32Z","timestamp":1661489492000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00340-18"}},"subtitle":[],"editor":[{"given":"Rozanne M.","family":"Sandri-Goldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":65,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1128\/JVI.00340-18"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00340-18","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/308171","asserted-by":"object"}]},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"2018-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00340-18"}}