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MuV-related hearing loss is also a serious complication because it is usually irreversible. MuV outbreaks have been reported in many countries, even in high-vaccine-coverage areas. MuV has tropism toward glandular tissues and the central nervous system. To understand the unique MuV tropism, revealing the mechanism of receptor recognition by MuV is very important. Here, using a large-scale glycan array and X-ray crystallography, we show that MuV recognizes sialyl Lewis\n            <jats:sup>X<\/jats:sup>\n            and GM2 ganglioside as receptors, in addition to a previously reported MuV receptor, a trisaccharide containing an \u03b12,3-linked sialic acid. The flexible recognition of these glycan receptors by MuV may explain the unique tropism and pathogenesis of MuV. Structures will also provide a template for the development of effective entry inhibitors targeting the receptor-binding site of MuV.\n          <\/jats:p>","DOI":"10.1128\/jvi.00344-19","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T07:58:44Z","timestamp":1558598324000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus"],"prefix":"10.1128","volume":"93","author":[{"given":"Marie","family":"Kubota","sequence":"first","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"RIKEN SPring-8 Center, Biostructural Mechanism Laboratory, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tateki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Yonekura","sequence":"additional","affiliation":[{"name":"RIKEN SPring-8 Center, Biostructural Mechanism Laboratory, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7815-1667","authenticated-orcid":false,"given":"Yusuke","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-7571","authenticated-orcid":false,"given":"Takao","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"1024","volume-title":"Fields virology","author":"Rubin SA","year":"2013","unstructured":"Rubin SA, Sauder CJ, Carbone KM. 2013. Mumps virus, p 1024\u20131041. In Knipe DM, Howley PM, Cohen JI, Griffin DE, Lamb RA, Martin MA, Racaniello VR, Roizman B (ed), Fields virology, 6 ed, vol 1. Lippincott Williams & Wilkins, Philadelphia, PA.","edition":"6"},{"issue":"04","key":"e_1_3_3_3_2","first-page":"1","article-title":"Prevention of measles, rubella, congenital rubella syndrome, and mumps, 2013: summary recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"62","author":"McLean HQ","year":"2013","unstructured":"McLean HQ, Fiebelkorn AP, Temte JL, Wallace GS, Centers for Disease Control and Prevention. 2013. Prevention of measles, rubella, congenital rubella syndrome, and mumps, 2013: summary recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 62(RR-04):1\u201334.","journal-title":"MMWR Recomm Rep"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.06.109"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004791"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31818a8ca8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60419-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/2331216514541361"},{"key":"e_1_3_3_9_2","first-page":"957","volume-title":"Fields virology","author":"Lamb RA","year":"2013","unstructured":"Lamb RA, Parks GD. 2013. Paramyxoviridae, p 957\u2013995. In Knipe DM, Howley PM, Cohen JI, Griffin DE, Lamb RA, Martin MA, Racaniello VR, Roizman B (ed), Fields virology, 6 ed, vol I. Lippincott Williams & Wilkins, Philadelphia, PA.","edition":"6"},{"key":"e_1_3_3_10_2","first-page":"1186","volume-title":"Fields virology","author":"Wright PF","year":"2013","unstructured":"Wright PF, Neumann G, Kawaoka Y. 2013. Orthomyxoviruses, p 1186\u20131243. In Knipe DM, Howley PM, Cohen JI, Griffin DE, Lamb RA, Martin MA, Racaniello VR, Roizman B (ed), Fields virology, 6 ed, vol I. 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