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One class of antiviral therapies may lie in known pregnancy-acceptable drugs that have the potential to mitigate arbovirus infections and disease, yet this has not been explored in detail. In this study, we show that the common antiparasitic drug atovaquone inhibits arbovirus replication through intracellular nucleotide depletion and can impair ZIKV infection in an\n                    <jats:italic>ex vivo<\/jats:italic>\n                    human placental explant model. Our study provides a novel function for atovaquone and highlights that the rediscovery of pregnancy-acceptable drugs with potential antiviral effects can be the key to better addressing the immediate need for treating viral infections and preventing potential birth complications and future disease.\n                  <\/jats:p>","DOI":"10.1128\/jvi.00389-19","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T07:20:34Z","timestamp":1552893634000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Atovaquone Inhibits Arbovirus Replication through the Depletion of Intracellular Nucleotides"],"prefix":"10.1128","volume":"93","author":[{"given":"Angelica","family":"Cifuentes Kottkamp","sequence":"first","affiliation":[{"name":"Department of Medicine, New York University School of Medicine, New York, New York, 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