{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:10:38Z","timestamp":1792714238919,"version":"4.5.0"},"reference-count":75,"publisher":"American Society for Microbiology","issue":"14","license":[{"start":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T00:00:00Z","timestamp":1310688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2011,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Studies with mice lacking the common plasma membrane receptor for type I interferon (\n            <jats:italic>IFN-\u03b1\u03b2R<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:sup>\/<\/jats:sup>\n            <jats:sup>\u2212<\/jats:sup>\n            ) have revealed that IFN signaling restricts tropism, dissemination, and lethality after infection with West Nile virus (WNV) or several other pathogenic viruses. However, the specific functions of individual IFN subtypes remain uncertain. Here, using\n            <jats:italic>IFN-\u03b2<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:sup>\/<\/jats:sup>\n            <jats:sup>\u2212<\/jats:sup>\n            mice, we defined the antiviral and immunomodulatory function of this IFN subtype in restricting viral infection.\n            <jats:italic>IFN-\u03b2<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:sup>\/<\/jats:sup>\n            <jats:sup>\u2212<\/jats:sup>\n            mice were more vulnerable to WNV infection than wild-type mice, succumbing more quickly and with greater overall mortality, although the phenotype was less severe than that of\n            <jats:italic>IFN-\u03b1\u03b2R<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:sup>\/<\/jats:sup>\n            <jats:sup>\u2212<\/jats:sup>\n            mice. The increased susceptibility of\n            <jats:italic>IFN-\u03b2<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:sup>\/<\/jats:sup>\n            <jats:sup>\u2212<\/jats:sup>\n            mice was accompanied by enhanced viral replication in different tissues. Consistent with a direct role for IFN-\u03b2 in control of WNV replication, viral titers in\n            <jats:italic>ex vivo<\/jats:italic>\n            cultures of macrophages, dendritic cells, fibroblasts, and cerebellar granule cell neurons, but not cortical neurons, from\n            <jats:italic>IFN-\u03b2<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:sup>\/<\/jats:sup>\n            <jats:sup>\u2212<\/jats:sup>\n            mice were greater than in wild-type cells. Although detailed immunological analysis revealed no major deficits in the quality or quantity of WNV-specific antibodies or CD8\n            <jats:sup>+<\/jats:sup>\n            T cells, we observed an altered CD4\n            <jats:sup>+<\/jats:sup>\n            CD25\n            <jats:sup>+<\/jats:sup>\n            FoxP3\n            <jats:sup>+<\/jats:sup>\n            regulatory T cell response, with greater numbers after infection. Collectively, these results suggest that IFN-\u03b2 controls WNV pathogenesis by restricting infection in key cell types and by modulating T cell regulatory networks.\n          <\/jats:p>","DOI":"10.1128\/jvi.00396-11","type":"journal-article","created":{"date-parts":[[2011,5,5]],"date-time":"2011-05-05T03:33:06Z","timestamp":1304566386000},"page":"7186-7194","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":103,"title":["Beta Interferon Controls West Nile Virus Infection and Pathogenesis in Mice"],"prefix":"10.1128","volume":"85","author":[{"given":"Helen M.","family":"Lazear","sequence":"first","affiliation":[{"name":"Departments of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia K.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Vogt","sequence":"additional","affiliation":[{"name":"Pathology &amp; Immunology, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Michael","family":"Gale","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195-7650"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110"},{"name":"Pathology &amp; Immunology, Washington University School of Medicine, St. Louis, Missouri 63110"},{"name":"Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.1100"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.9.5839"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011666"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.90"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01933-06"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1996.16.489"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01190-10"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737196"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.12.8568"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01152-06"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200637009"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.4343"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00232-11"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030106"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00935-08"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00918-08"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000607"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.7.3404-3409.2000"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000136824.73458.20"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612023393288"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2230460100"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.11.4957-4966.2000"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.4.2578-2586.2003"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70086-7"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200635993"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.01.075"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01305-07"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.7.3438-3444.2006"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00446-07"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.11.5532-5539.2002"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1997.17.197"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164206"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R700002200"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03464"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1957.0048"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1303"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.17.11457-11466.2005"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.11.1971"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01718-06"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050821"},{"key":"e_1_3_2_42_2","first-page":"3266","article-title":"Tregs control the development of symptomatic West Nile virus infection in humans and mice","volume":"119","author":"Lanteri M. 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