{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T17:10:08Z","timestamp":1786468208267,"version":"build-2736575974"},"reference-count":78,"publisher":"American Society for Microbiology","issue":"15","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ZUK63"],"award-info":[{"award-number":["ZUK63"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,7,16]]},"abstract":"<jats:p>Viral vectors are widely used for the development of therapeutic vaccines for the treatment of tumors. In our study we have used Orf virus (ORFV) strain D1701-V for the generation of recombinant vaccines expressing cottontail rabbit papillomavirus (CRPV) early proteins E1, E2, LE6, and E7. The therapeutic efficacy of the ORFV-CRPV vaccines was evaluated in two independent experiments using the outbred CRPV rabbit model. In both experiments the immunization achieved significant suppression of tumor growth. In total, 84.6% of all outbred animals benefited from the ORFV-CRPV vaccination, showing reduction in tumor size and significant tumor growth inhibition, including one animal with complete tumor regression without recurrence.<\/jats:p>","DOI":"10.1128\/jvi.00398-20","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T14:02:19Z","timestamp":1589378539000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Orf Virus-Based Therapeutic Vaccine for Treatment of Papillomavirus-Induced Tumors"],"prefix":"10.1128","volume":"94","author":[{"given":"M.","family":"Schneider","sequence":"first","affiliation":[{"name":"University Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"University of Tuebingen, Interfaculty Institute for Cell Biology, Department of Immunology, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Yigitliler","sequence":"additional","affiliation":[{"name":"University Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Xi","sequence":"additional","affiliation":[{"name":"University Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Simon","sequence":"additional","affiliation":[{"name":"University Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Feger","sequence":"additional","affiliation":[{"name":"University of Tuebingen, Interfaculty Institute for Cell Biology, Department of Immunology, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-J.","family":"Rziha","sequence":"additional","affiliation":[{"name":"University of Tuebingen, Interfaculty Institute for Cell Biology, Department of Immunology, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Stubenrauch","sequence":"additional","affiliation":[{"name":"University Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-G.","family":"Rammensee","sequence":"additional","affiliation":[{"name":"University of Tuebingen, Interfaculty Institute for Cell Biology, Department of Immunology, Tuebingen, Germany"},{"name":"German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Partner Site Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Iftner","sequence":"additional","affiliation":[{"name":"University Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Amann","sequence":"additional","affiliation":[{"name":"University of Tuebingen, Interfaculty Institute for Cell Biology, Department of Immunology, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-031413-085442"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.318"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700538"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652311795684731"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3008-1_12"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0450.2002.00539.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-1702(02)00117-x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/v11020127"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.17.9312-9323.2003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.12.004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.09.121"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02470-12"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2017-0113"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.06.004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2016.07.002"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i5.1002"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.16"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/v9090245"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1822"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009933108"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.04.013"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0273"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2009.06.008"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.04.026"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.06.006"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.02.004"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.22.11209-11215.2002"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2672"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005366"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.70.2.960-965.1996"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/095632020501600602"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.08.012"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.04.082"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.06.012"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.1.116-123.2004"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.6.3959-3963.1995"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410x(95)00103-8"},{"key":"e_1_3_2_39_2","first-page":"222","article-title":"A novel recombinant papillomavirus genome enabling in vivo RNA interference reveals that YB-1, which interacts with the viral regulatory protein E2, is required for CRPV-induced tumor formation in vivo","volume":"4","author":"Leiprecht N","year":"2014","unstructured":"Leiprecht N, Notz E, Schuetz J, Haedicke J, Stubenrauch F, Iftner T. 2014. A novel recombinant papillomavirus genome enabling in vivo RNA interference reveals that YB-1, which interacts with the viral regulatory protein E2, is required for CRPV-induced tumor formation in vivo. Am J Cancer Res 4:222\u2013233.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2012.09.008"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.11.006"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.14.7478-7489.2004"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.04.049"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trivac.2014.06.002"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.20.9712-9716.2000"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.11.8467-8474.1997"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.03.016"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02835-06"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1150"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.111"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h988"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines2020422"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pvr.2017.12.006"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2017.09.008"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083802"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2018.0294"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.301"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82678-0"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24804"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.12.002"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0973-7"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3394"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26019"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/356066a0"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12395285"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050496"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00356-9"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605130103"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811584106"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00704-18"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1307"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.25.5817"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444998010889"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1006\/prep.2001.1451"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2006.04.017"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(89)90388-7"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.16.8736-8744.2003"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.13.2620"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1159\/000233004"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00398-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00398-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T14:57:10Z","timestamp":1646492230000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00398-20"}},"subtitle":[],"editor":[{"given":"Lawrence","family":"Banks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,16]]},"references-count":78,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,7,16]]}},"alternative-id":["10.1128\/JVI.00398-20"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00398-20","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,16]]},"assertion":[{"value":"2020-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00398-20"}}