{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:45:06Z","timestamp":1791308706888,"version":"4.3.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We studied the susceptibility of human embryonic stem cell-derived oligodendrocyte progenitor cells to infection with JC virus, the causative agent of progressive multifocal leukoencephalopathy (PML). A human embryonic stem cell line, H7, was used to derive an enriched population of cells expressing the oligodendrocyte progenitor cell-specific marker NG2. These cells expressed the 5HT\n            <jats:sub>2a<\/jats:sub>\n            receptor (5HT\n            <jats:sub>2a<\/jats:sub>\n            R) for JC virus and were highly susceptible to infection. Infection was reduced by treatment with anti-5HT\n            <jats:sub>2a<\/jats:sub>\n            R antibodies and by the 5HT\n            <jats:sub>2a<\/jats:sub>\n            R antagonists ritanserin and ketanserin. This is the first demonstration that human embryonic stem cell-derived oligodendrocyte progenitor cells are susceptible to JC virus infection and indicates that cells poised to replenish mature oligodendrocytes in PML lesions may also be a target of viral infection.\n          <\/jats:p>","DOI":"10.1128\/jvi.00406-08","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T00:46:13Z","timestamp":1214441173000},"page":"8896-8899","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cells Express the Serotonin Receptor and Are Susceptible to JC Virus Infection"],"prefix":"10.1128","volume":"82","author":[{"given":"C.","family":"Schaumburg","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California"},{"name":"Sue and Bill Gross Stem Cell Research Center, Irvine, California 92697"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. A.","family":"O'Hara","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. E.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California"},{"name":"Sue and Bill Gross Stem Cell Research Center, Irvine, California 92697"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"Atwood","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/81.1.93"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.21.10290-10299.2001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.1.238-245.2000"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.02.018"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02123-07"},{"key":"e_1_3_2_7_2","first-page":"1241","volume":"306","year":"2004","unstructured":"Fonseca-Elphick, G., W. Querbes, J. A. Jordan, G. V. Gee, S. Eash, K. Manley, A. Dugan, M. Stanifer, A. Bhatnagar, W. K. Kroeze, B. L. Roth, and W. J. Atwood. 2004. 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