{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:56:13Z","timestamp":1790816173830,"version":"4.1.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T00:00:00Z","timestamp":1339718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2012,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Variants near the<jats:italic>HLA-DP<\/jats:italic>gene show the strongest genome-wide association with chronic hepatitis B virus (HBV) infection and HBV recovery\/persistence in Asians. To test the effect of the HLA-DP region on outcomes to HBV infection, we sequenced the polymorphic<jats:italic>HLA-DPB1<\/jats:italic>and<jats:italic>DPA1<\/jats:italic>coding exons and the corresponding 3\u2032 untranslated regions (3\u2032UTRs) in 662 individuals of European-American and African-American ancestry. The genome-wide association study (GWAS) variant (<jats:italic>rs9277535<\/jats:italic>;<jats:italic>550A\/G<\/jats:italic>) in the 3\u2032UTR of the<jats:italic>HLA-DPB1<\/jats:italic>gene that associated most significantly with chronic hepatitis B and outcomes to HBV infection in Asians had a marginal effect on HBV recovery in our European- and African-American samples (odds ratio [OR] = 0.39,<jats:italic>P<\/jats:italic>= 0.01, combined ethnic groups). However, we identified a novel variant in the<jats:italic>HLA-DPB1<\/jats:italic>3\u2032UTR region,<jats:italic>496A\/G<\/jats:italic>(<jats:italic>rs9277534<\/jats:italic>), which associated very significantly with HBV recovery in both European and African-American populations (OR = 0.37,<jats:italic>P<\/jats:italic>= 0.0001, combined ethnic groups). The<jats:italic>496A\/G<\/jats:italic>variant distinguishes the most protective<jats:italic>HLA-DPB1<\/jats:italic>allele (<jats:italic>DPB1<\/jats:italic>*<jats:italic>04:01<\/jats:italic>) from the most susceptible (<jats:italic>DPB1<\/jats:italic>*<jats:italic>01:01<\/jats:italic>), whereas<jats:italic>550A\/G<\/jats:italic>does not.<jats:italic>496A\/G<\/jats:italic>has a stronger effect than any individual<jats:italic>HLA-DPB1<\/jats:italic>or<jats:italic>DPA1<\/jats:italic>allele and any other<jats:italic>HLA<\/jats:italic>alleles that showed an association with HBV recovery in our European-American cohort. The<jats:italic>496GG<\/jats:italic>genotype, which confers recessive susceptibility to HBV persistence, also associates in a recessive manner with significantly higher levels of HLA-DP surface protein and transcript level expression in healthy donors, suggesting that differences in expression of HLA-DP may increase the risk of persistent HBV infection.<\/jats:p>","DOI":"10.1128\/jvi.00406-12","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T05:16:50Z","timestamp":1334207810000},"page":"6979-6985","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":145,"title":["A Novel Variant Marking HLA-DP Expression Levels Predicts Recovery from Hepatitis B Virus Infection"],"prefix":"10.1128","volume":"86","author":[{"given":"Rasmi","family":"Thomas","sequence":"first","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA, and Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe L.","family":"Thio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Apps","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA, and Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qi","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA, and Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA, and Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene","family":"Marti","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, USA, and Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy L.","family":"Stein","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A.","family":"Soderberg","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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