{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:18:48Z","timestamp":1776356328099,"version":"3.51.2"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"21","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001843","name":"DST | Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2017\/001490"],"award-info":[{"award-number":["EMR\/2017\/001490"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/1\/3\/JRF-2014\/HRD-98 (31555)"],"award-info":[{"award-number":["3\/1\/3\/JRF-2014\/HRD-98 (31555)"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:p>Microglial cells, the resident macrophages in the brain, play a vital role in Japanese encephalitis virus (JEV) pathogenesis. The deregulated activity of microglia can be lethal for the brain.<\/jats:p>","DOI":"10.1128\/jvi.00406-21","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T14:30:49Z","timestamp":1628692249000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Lack of Interferon (IFN) Regulatory Factor 8 Associated with Restricted IFN-\u03b3 Response Augmented Japanese Encephalitis Virus Replication in the Mouse Brain"],"prefix":"10.1128","volume":"95","author":[{"given":"Aarti","family":"Tripathi","sequence":"first","affiliation":[{"name":"Translational Health Science and Technology Institute (THSTI), Faridabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhupendra","family":"Singh Rawat","sequence":"additional","affiliation":[{"name":"National Institute of Immunology (NII), New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sankar","family":"Addya","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Surjit","sequence":"additional","affiliation":[{"name":"Translational Health Science and Technology Institute (THSTI), Faridabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prafullakumar","family":"Tailor","sequence":"additional","affiliation":[{"name":"National Institute of Immunology (NII), New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhanshu","family":"Vrati","sequence":"additional","affiliation":[{"name":"Regional Center for Biotechnology (RCB), Faridabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-1763","authenticated-orcid":true,"given":"Arup","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Translational Health Science and Technology Institute (THSTI), Faridabad, India"},{"name":"Regional Center for Biotechnology (RCB), Faridabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.10.085233"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.19693.1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/890586"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.02.014"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.018"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2013.78.020305"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-018-0599-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003491"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.04.030"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.544320"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-227"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-020-02154-2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2304"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.11.022"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-97"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/423328"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1375"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03059"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-294272"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86276"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201453109"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"154.1","DOI":"10.4049\/jimmunol.186.Supp.154.1","article-title":"Increased lethality but decreased encephalitis in IRF8-deficient mice following West Nile virus infection","volume":"186","author":"Minten C","year":"2011","unstructured":"Minten C, Terry R, King N, Campbell I. 2011. Increased lethality but decreased encephalitis in IRF8-deficient mice following West Nile virus infection. J Immunol 186:154.1.","journal-title":"J Immunol"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.04.019"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1102577"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000365972"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-73"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.4049\/jimmunol.152.2.841","article-title":"Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha","volume":"152","author":"Norris JG","year":"1994","unstructured":"Norris JG, Tang LP, Sparacio SM, Benveniste EN. 1994. Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha. J Immunol 152:841\u2013850.","journal-title":"J Immunol"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(10)80037-X"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2010.00445.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"6896","DOI":"10.4049\/jimmunol.161.12.6896","article-title":"Astrocyte-derived monocyte-chemoattractant protein-1 directs the transmigration of leukocytes across a model of the human blood-brain barrier","volume":"161","author":"Weiss JM","year":"1998","unstructured":"Weiss JM, Downie SA, Lyman WD, Berman JW. 1998. Astrocyte-derived monocyte-chemoattractant protein-1 directs the transmigration of leukocytes across a model of the human blood-brain barrier. J Immunol 161:6896\u20136903.","journal-title":"J Immunol"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.681361"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.013565-0"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81348-3"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201243152"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.4049\/jimmunol.148.3.801","article-title":"Modulation of interferon consensus sequence binding protein mRNA in murine peritoneal macrophages. Induction by IFN-gamma and down-regulation by IFN-alpha, dexamethasone, and protein kinase inhibitors","volume":"148","author":"Politis AD","year":"1992","unstructured":"Politis AD, Sivo J, Driggers PH, Ozato K, Vogel SN. 1992. Modulation of interferon consensus sequence binding protein mRNA in murine peritoneal macrophages. Induction by IFN-gamma and down-regulation by IFN-alpha, dexamethasone, and protein kinase inhibitors. J Immunol 148:801\u2013807.","journal-title":"J Immunol"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.4049\/jimmunol.152.5.2270","article-title":"Regulation of IFN-gamma-induced nuclear expression of IFN consensus sequence binding protein in murine peritoneal macrophages","volume":"152","author":"Politis AD","year":"1994","unstructured":"Politis AD, Ozato K, Coligan JE, Vogel SN. 1994. Regulation of IFN-gamma-induced nuclear expression of IFN consensus sequence binding protein in murine peritoneal macrophages. J Immunol 152:2270\u20132278.","journal-title":"J Immunol"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.07.006"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203541"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2020.104043"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00406-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00406-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T23:47:24Z","timestamp":1673048844000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00406-21"}},"subtitle":[],"editor":[{"given":"Bryan R. G.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":41,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,10,13]]}},"alternative-id":["10.1128\/JVI.00406-21"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00406-21","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740634134.793589377","asserted-by":"object"}]},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,13]]},"assertion":[{"value":"2021-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00406-21"}}