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By studying serial liver and blood samples of five vaccinated and five mock-vaccinated control chimpanzees during acute HCV infection, we demonstrate a correlation between HCV-specific CD8 T-cell responses in the blood and molecular and functional markers of T-cell responses in the liver. Thus, HCV-specific CD8 T-cell responses in the blood are valid markers for intrahepatic T-cell activity.<\/jats:p>","DOI":"10.1128\/jvi.00475-08","type":"journal-article","created":{"date-parts":[[2008,7,31]],"date-time":"2008-07-31T00:55:28Z","timestamp":1217465728000},"page":"9782-9788","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["The Kinetics of Hepatitis C Virus-Specific CD8 T-Cell Responses in the Blood Mirror Those in the Liver in Acute Hepatitis C Virus Infection"],"prefix":"10.1128","volume":"82","author":[{"given":"Eui-Cheol","family":"Shin","sequence":"first","affiliation":[{"name":"Immunology Section, Liver Diseases Branch, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Capone","sequence":"additional","affiliation":[{"name":"Okairos, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Cortese","sequence":"additional","affiliation":[{"name":"Okairos, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Colloca","sequence":"additional","affiliation":[{"name":"Okairos, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Nicosia","sequence":"additional","affiliation":[{"name":"Okairos, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Folgori","sequence":"additional","affiliation":[{"name":"Okairos, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Rehermann","sequence":"additional","affiliation":[{"name":"Immunology Section, Liver Diseases Branch, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02235.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9505"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24371"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.15.7059-7066.2001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91691-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1353"},{"key":"e_1_3_2_8_2","first-page":"327","volume":"242","year":"2000","unstructured":"Houghton, M. 2000. 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