{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:25:48Z","timestamp":1782840348091,"version":"3.54.5"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"16","license":[{"start":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T00:00:00Z","timestamp":1218758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2008,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:italic>Caliciviridae<\/jats:italic>\n            family comprises positive-sense RNA viruses of medical and veterinary significance. In humans, caliciviruses are a major cause of acute gastroenteritis, while in animals respiratory illness, conjunctivitis, stomatitis, and hemorrhagic disease are documented. Investigation of virus-host interactions is limited by a lack of culture systems for many viruses in this family. Feline calicivirus (FCV), a member of the\n            <jats:italic>Vesivirus<\/jats:italic>\n            genus, provides a tractable model, since it may be propagated in cell culture. Feline junctional adhesion molecule 1 (fJAM-1) was recently identified as a functional receptor for FCV. We have analyzed the structure of this virus-receptor complex by cryo-electron microscopy and three-dimensional image reconstruction, combined with fitting of homology modeled high-resolution coordinates. We show that domain 1 of fJAM-1 binds to the outer face of the P2 domain of the FCV capsid protein VP1, inducing conformational changes in the viral capsid. This study provides the first structural view of a native calicivirus-protein receptor complex and insights into the mechanisms of virus attachment and uncoating.\n          <\/jats:p>","DOI":"10.1128\/jvi.00550-08","type":"journal-article","created":{"date-parts":[[2008,6,13]],"date-time":"2008-06-13T01:04:06Z","timestamp":1213319046000},"page":"8051-8058","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["Structural Insights into Calicivirus Attachment and Uncoating"],"prefix":"10.1128","volume":"82","author":[{"given":"David","family":"Bhella","sequence":"first","affiliation":[{"name":"Medical Research Council Virology Unit, Glasgow University, Church St., Glasgow G11 5JR, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Gatherer","sequence":"additional","affiliation":[{"name":"Medical Research Council Virology Unit, Glasgow University, Church St., Glasgow 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