{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T19:44:43Z","timestamp":1769975083100,"version":"3.49.0"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Intramuscular inoculation of rhesus macaques with one or more doses of recombinant vesicular stomatitis virus (rVSV) expressing human immunodeficiency virus type 1 (HIV-1) Gag (rVSVgag) typically elicits peak cellular immune responses of 500 to 1,000 gamma interferon (IFN-\u03b3) enzyme-linked immunospots (ELISPOTS)\/10\n            <jats:sup>6<\/jats:sup>\n            peripheral blood lymphocytes (PBL). Here, we describe the generation of a novel recombinant mumps virus (rMuV) expressing HIV-1 Gag (rMuVgag) and measure the Gag-specific cellular immune responses detected in rhesus macaques following vaccination with a highly attenuated form of rVSV expressing HIV-1 Gag (rVSVN4CT1gag1) and rMuVgag in various prime-boost combinations. Notably, peak Gag-specific cellular immune responses of 3,000 to 3,500 ELISPOTS\/10\n            <jats:sup>6<\/jats:sup>\n            PBL were detected in macaques that were primed with rMuVgag and boosted with rVSVN4CT1gag1. Lower peak cellular immune responses were detected in macaques that were primed with rVSVN4CT1gag1 and boosted with rMuVgag, although longer-term gag-specific responses appeared to remain higher in this group of macaques. These findings indicate that rMuVgag may significantly enhance Gag-specific cellular immune responses when administered with rVSVN4CT1gag1 in heterologous prime-boost regimens.\n          <\/jats:p>","DOI":"10.1128\/jvi.00550-09","type":"journal-article","created":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T01:09:51Z","timestamp":1248311391000},"page":"9813-9823","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Prime-Boost Vaccination with Recombinant Mumps Virus and Recombinant Vesicular Stomatitis Virus Vectors Elicits an Enhanced Human Immunodeficiency Virus Type 1 Gag-Specific Cellular Immune Response in Rhesus Macaques"],"prefix":"10.1128","volume":"83","author":[{"given":"R.","family":"Xu","sequence":"first","affiliation":[{"name":"Wyeth Vaccines Discovery Research, 401 North Middletown Road, Pearl River, New York 10965"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Nasar","sequence":"additional","affiliation":[{"name":"Wyeth Vaccines Discovery Research, 401 North Middletown Road, Pearl River, New York 10965"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Megati","sequence":"additional","affiliation":[{"name":"Wyeth Vaccines Discovery Research, 401 North Middletown Road, Pearl River, New York 10965"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Luckay","sequence":"additional","affiliation":[{"name":"Wyeth Vaccines Discovery Research, 401 North Middletown Road, Pearl River, New York 10965"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Wyeth Vaccines Discovery Research, 401 North Middletown Road, Pearl River, New York 10965"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Udem","sequence":"additional","affiliation":[{"name":"Wyeth Vaccines Discovery Research, 401 North Middletown Road, Pearl River, New York 10965"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Eldridge","sequence":"additional","affiliation":[{"name":"Wyeth Vaccines Discovery Research, 401 North Middletown Road, Pearl River, New York 10965"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Egan","sequence":"additional","affiliation":[{"name":"Wyeth Vaccines Discovery Research, 401 North Middletown Road, Pearl River, New York 10965"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Emini","sequence":"additional","affiliation":[{"name":"Wyeth Vaccines Discovery Research, 401 North Middletown Road, Pearl River, New York 10965"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. K.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Wyeth Vaccines Discovery Research, 401 North Middletown Road, Pearl River, New York 10965"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00459-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058915"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.15.7625-7631.2002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/319863"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/315229"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.8.4822-4830.1993"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.11.6305-6313.2003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-006-0042-3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01911-06"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.10.4831-4838.2000"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.21.11546-11554.2003"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01515-07"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.21.11563-11577.2003"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.16.7485-7495.2000"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2005.21.629"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2004.20.989"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.08.024"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.6.1623"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-11-2893"},{"key":"e_1_3_2_21_2","first-page":"165","volume":"292","year":"2005","unstructured":"Finke, S., and K. K. Conzelmann. 2005. Recombinant rhabdoviruses: vectors for vaccine development and gene therapy. Curr. Top. Microbiol. Immunol.292:165-200.","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90873-8"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.15.5781"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-200203010-00005"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.9.7524-7532.1999"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80726-7"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90143-4"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.10.026"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1258"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a120738"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.22.11079-11087.2001"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.06.016"},{"key":"e_1_3_2_33_2","unstructured":"Fields virology 2007"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00266-07"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1959"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.2515\/therapie:2005029"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.04.024"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.1.146-157.2004"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1086\/515613"},{"key":"e_1_3_2_40_2","unstructured":"Guide for the Care and Use of Laboratory Macaques. 1996"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.8.3930-3940.2004"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.17.8900-8909.2002"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.5.3723-3732.1999"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.6.4704-4711.1998"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/8406"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030157"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00482-2"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.23.10903-10910.2000"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00744-07"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/415331a"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2005.18.317"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121284"},{"key":"e_1_3_2_53_2","first-page":"216","volume":"91","year":"1970","unstructured":"Tesh, R. B., P. H. Peralta, and K. M. Johnson. 1970. Ecologic studies of vesicular stomatitis virus. II. Results of experimental infection in Panamanian wild animals. Am. J. Epidemiol.91:216-224.","journal-title":"II. Results of experimental infection in Panamanian wild animals. Am. J. Epidemiol."},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04790"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2006.02.006"},{"key":"e_1_3_2_56_2","first-page":"161","volume":"16","year":"1973","unstructured":"Yamanishi, K., M. Takahashi, S. Ueda, Y. Minekawa, and T. Ogino. 1973. Studies on live mumps virus vaccine. V. Development of a new mumps vaccine \u201cAM 9\u201d by plaque cloning. Biken J.16:161-166.","journal-title":"Biken J."}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00550-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00550-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:35:37Z","timestamp":1646483737000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00550-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":55,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1128\/JVI.00550-09"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00550-09","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"2009-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}