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More studies are required to determine their exact epidemiology, but several reports have already identified them as the cause of unexpected clinical diseases, including severe neurologic diseases. Our study provides the first description of a cell culture system for the propagation of MLB astroviruses, enabling the study of their replicative cycle. Moreover, we demonstrated the unknown capacity of MLB astrovirus to establish persistent infections in cell culture. Whether these persistent infections are also established\n            <jats:italic>in vivo<\/jats:italic>\n            remains unknown, but the clinical consequences would be of high interest if persistence was confirmed\n            <jats:italic>in vivo<\/jats:italic>\n            . 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