{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:25:10Z","timestamp":1648589110351},"reference-count":36,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>APOBEC3 proteins mediate potent antiretroviral activity by hypermutating the retroviral genome during reverse transcription. To counteract APOBEC3 and gain a replicative advantage, lentiviruses such as human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) have evolved the Vif protein, which targets APOBEC3 proteins for proteasomal degradation. However, the proteasome plays a critical role in the generation of T cell peptide epitopes. Whether Vif-mediated destruction of APOBEC3 proteins leads to the generation and presentation of APOBEC3-derived T cell epitopes on the surfaces of lentivirus-infected cells remains unknown. Here, using peptides derived from multiple Vif-sensitive APOBEC3 proteins, we identified APOBEC3-specific T cell responses in both HIV-1-infected patients and SIV-infected rhesus macaques. These results raise the possibility that these T cell responses may be part of the larger antiretroviral immune response.<\/jats:p>","DOI":"10.1128\/jvi.00579-12","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T01:54:33Z","timestamp":1364435673000},"page":"6073-6080","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["T Cells Target APOBEC3 Proteins in Human Immunodeficiency Virus Type 1-Infected Humans and Simian Immunodeficiency Virus-Infected Indian Rhesus Macaques"],"prefix":"10.1128","volume":"87","author":[{"given":"St\u00e9phane","family":"Champiat","sequence":"first","affiliation":[{"name":"Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA"},{"name":"Universit\u00e9 Pierre et Marie Curie-Paris 6, Medical School, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith E.","family":"Garrison","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA"},{"name":"Department of Biology, Saint Mary's College of California, Moraga, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui Andr\u00e9 Saraiva","family":"Raposo","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Burwitz","sequence":"additional","affiliation":[{"name":"Vaccine &amp; Gene Therapy Institute, Oregon Health &amp; Science University, Beaverton, Oregon, 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