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This mechanism, also termed selective autophagy, is well characterized for invasive bacteria but remains poorly documented for viral infections. Here we highlight our recent work showing that endosomolytic adenoviruses trigger autophagy when entering cells. Our study revealed how adenoviruses exploit a capsid-associated small PPxY peptide motif to manipulate the autophagic machinery to prevent autophagic degradation and to promote endosomal escape and nuclear trafficking.<\/jats:p>","DOI":"10.1128\/jvi.00581-17","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:30:22Z","timestamp":1498696222000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["A Small Viral PPxY Peptide Motif To Control Antiviral Autophagy"],"prefix":"10.1128","volume":"91","author":[{"given":"Charlotte","family":"Montespan","sequence":"first","affiliation":[{"name":"CNRS UMR 5234, Microbiologie Fondamentale et Pathog\u00e9nicit\u00e9, Universit\u00e9 de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Wiethoff","sequence":"additional","affiliation":[{"name":"Biologics ADME, Drug Disposition Labs, Lilly Corporate Center, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4764-1708","authenticated-orcid":false,"given":"Harald","family":"Wodrich","sequence":"additional","affiliation":[{"name":"CNRS UMR 5234, Microbiologie Fondamentale et Pathog\u00e9nicit\u00e9, Universit\u00e9 de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.4.1992-2000.2005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.03.043"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-601-6_15"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01428-12"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02257-14"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000808"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006217"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01415.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10744"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000068"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/bse0550065"},{"key":"e_1_3_2_13_2","first-page":"71","article-title":"Physiological functions of autophagy","volume":"335","author":"Mizushima N","year":"2009","unstructured":"Mizushima N . 2009. 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