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Dengue virus (DENV; serotypes 1 to 4), a member of the\n            <jats:italic>Flavivirus<\/jats:italic>\n            genus of the\n            <jats:italic>Flaviviridae<\/jats:italic>\n            family, causes millions of infections annually. Development of a safe vaccine is hampered due to absence of cross-protection and increased risk in secondary infections due to antibody-mediated immune enhancement. Infection of vector mosquitoes with\n            <jats:italic>Wolbachia<\/jats:italic>\n            bacteria offers a novel countermeasure to suppress DENV transmission, but the mechanisms are poorly understood. In this study, the host transcription profiles and viral RNA sequences were analyzed in naive\n            <jats:named-content content-type=\"genus-species\">A. albopictus<\/jats:named-content>\n            (C6\/36) and\n            <jats:italic>w<\/jats:italic>\n            MelPop-C6\/36 cells by RNAseq. Our results showed that the\n            <jats:italic>w<\/jats:italic>\n            MelPop symbiont caused profound changes in host transcription profiles and morphology of DENV2-infected C6\/36 cells. Accumulation of several mutations throughout DENV2 RNA resulted in loss of infectivity of progeny virions. Our findings offer new insights into the mechanism of\n            <jats:italic>Wolbachia<\/jats:italic>\n            -mediated suppression of DENV transmission.\n          <\/jats:p>","DOI":"10.1128\/jvi.00581-19","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T07:56:16Z","timestamp":1558598176000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Infection of Aedes albopictus Mosquito C6\/36 Cells with the\n            <i>w<\/i>\n            Melpop Strain of\n            <i>Wolbachia<\/i>\n            Modulates Dengue Virus-Induced Host Cellular Transcripts and Induces Critical Sequence Alterations in the Dengue Viral Genome"],"prefix":"10.1128","volume":"93","author":[{"given":"Tadahisa","family":"Teramoto","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Armbruster","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishnan","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_3_2_3_2","first-page":"1101","volume-title":"Field\u2019s virology","author":"Lindenbach D","year":"2007","unstructured":"Lindenbach D, Thiel HJ, Rice C. 2007. Flaviviridae: the viruses and their replication, p 1101\u20131152. In Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (ed), Field\u2019s virology, 5th ed, vol 1. Lippincott Williams & Wilkins, Philadelphia, PA.","edition":"5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00072-15"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.9.4364-4374.1990"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.11.6042-6050.1991"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.5.2467-2475.1991"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.12.7549-7554.1992"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.49.30715"},{"key":"e_1_3_2_10_2","first-page":"14","volume-title":"Frontiers in dengue virus research","author":"Padmanabhan R","year":"2010","unstructured":"Padmanabhan R, Strongin AY. 2010. 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