{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:32:03Z","timestamp":1789543923735,"version":"build-2803163510"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"15","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["7R21CA192185-02"],"award-info":[{"award-number":["7R21CA192185-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG16901"],"award-info":[{"award-number":["IG16901"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>The use of nonpathogenic viruses to target and kill cancer cells is a promising strategy in cancer therapy. However, many types of human cancer are resistant to the oncolytic (cancer-killing) effects of virotherapy. In this study, we identify a host cellular protein, SIRT1, that contributes to the sensitivity of prostate cancer cells to infection by a prototypical oncolytic virus. Knockout of SIRT1 activity increases the sensitivity of prostate cancer cells to virus-mediated killing. At the molecular level, SIRT1 is controlled by a small microRNA termed miR-34a. Altogether, SIRT1 and\/or miR-34a levels may serve as predictors of response to oncolytic-virus therapy.<\/jats:p>","DOI":"10.1128\/jvi.00626-19","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T07:51:08Z","timestamp":1558597868000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis"],"prefix":"10.1128","volume":"93","author":[{"given":"Michela","family":"Muscolini","sequence":"first","affiliation":[{"name":"Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Castiello","sequence":"additional","affiliation":[{"name":"Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Palermo","sequence":"additional","affiliation":[{"name":"Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Zevini","sequence":"additional","affiliation":[{"name":"Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Olagnier","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hiscott","sequence":"additional","affiliation":[{"name":"Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.06.046"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3770"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-016-0158-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-652503"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw379.04"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2287"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/77558"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00241-1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803988105"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03406-13"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070140"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092250"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2014.05.005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0085"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-015-0706-8"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3760\/cma.j.issn.0366-6999.20140044","article-title":"Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer","volume":"127","author":"Jiang K","year":"2014","unstructured":"Jiang K, Lyu L, Shen Z, Zhang J, Zhang H, Dong J, Yan Y, Liu F, Wang S. 2014. Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer. Chin Med J (Engl) 127:2021\u20132024.","journal-title":"Chin Med J (Engl)"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.06.045"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2011.02888.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S37750"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947601912475079"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3365"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2010.05.002"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.01.011"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0309-228"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801613105"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0117"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3645"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.09.086"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02249-14"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.77"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12359"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306552200"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi034959l"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01229-15"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.283"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.04.022"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.03.002"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403910"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4110\/in.2016.16.5.286"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3386"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1448"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-6-37"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116480"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600244"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.7101"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-13-4"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.07056-11"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394387-3.00005-7"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.06.068"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707351104"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2642"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.148"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024099"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094637"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00626-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00626-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T12:43:10Z","timestamp":1721306590000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00626-19"}},"subtitle":[],"editor":[{"given":"Adolfo","family":"Garc\u00eda-Sastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":54,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1128\/JVI.00626-19"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00626-19","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"2019-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00626-19"}}