{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:45:29Z","timestamp":1791315929225,"version":"4.3.1"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"21","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R37-AI064046"],"award-info":[{"award-number":["R37-AI064046"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K99-AI147811"],"award-info":[{"award-number":["K99-AI147811"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,10,14]]},"abstract":"<jats:p>\n            A critical function of HIV-1 Vif is to counteract the family of APOBEC3 innate immune proteins. It is also widely accepted that Vif induces G\n            <jats:sub>2<\/jats:sub>\n            \/M cell cycle arrest in several different cell types. Recently, it has been shown that Vif degrades multiple PPP2R5 phosphoregulators to induce the G\n            <jats:sub>2<\/jats:sub>\n            \/M arrest phenotype. Here, computational approaches are used to test a structural model of the Vif\/PPP2R5 complex. In addition, imaging studies are used to show that Vif degrades these PPP2R5 substrates in roughly the same time frame as APOBEC3 degradation and that this activity is prevalent in patient-derived Vif isolates. These studies are important by further defining PPP2R5 proteins as a bona fide substrate of HIV-1 Vif.\n          <\/jats:p>","DOI":"10.1128\/jvi.00631-20","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T13:36:15Z","timestamp":1598276175000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Functional and Structural Insights into a Vif\/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling"],"prefix":"10.1128","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-2684","authenticated-orcid":false,"given":"Daniel J.","family":"Salamango","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA"},{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA"},{"name":"Institute for Molecular Virology, 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