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It still unknown how the mitochondrial response changes in cells infected with viruses in the process of virulence attenuation. EIAV\n            <jats:sub>DLV121<\/jats:sub>\n            is the only effective lentiviral vaccine for large-scale use in the world. EIAV\n            <jats:sub>DLV34<\/jats:sub>\n            is the parent pathogenic strain. Unlike EIAV\n            <jats:sub>DLV34<\/jats:sub>\n            -induced inflammation storms, EIAV\n            <jats:sub>DLV121<\/jats:sub>\n            can induce high levels of apoptosis. For the first time, we found that, after the mitochondrial protein expression profile is altered, EIAV\n            <jats:sub>DLV34<\/jats:sub>\n            -infected cells are transformed into M1-polarized-type macrophages and cause inflammatory injury and that the intrinsic apoptosis pathway is activated in EIAV\n            <jats:sub>DLV121<\/jats:sub>\n            -infected cells. These studies shed light on how the mitochondrial protein expression profile changes between cells infected by pathogenic lentivirus strains and cells infected by attenuated lentivirus strains to drive different cellular responses, especially from inflammation to apoptosis.\n          <\/jats:p>","DOI":"10.1128\/jvi.00653-19","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T09:37:08Z","timestamp":1565257028000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Attenuation of Equine Lentivirus Alters Mitochondrial Protein Expression Profile from Inflammation to Apoptosis"],"prefix":"10.1128","volume":"93","author":[{"given":"Cheng","family":"Du","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 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