{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:48:01Z","timestamp":1791341281226,"version":"4.3.1"},"reference-count":65,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Infection with the human T-cell leukemia virus type 1 (HTLV-1) results in a variety of diseases including adult T-cell leukemia (ATL), a fatal malignancy characterized by the uncontrolled proliferation of virally infected CD4\n            <jats:sup>+<\/jats:sup>\n            T cells. The HTLV-1 basic leucine zipper factor (HBZ) is believed to contribute to development and maintenance of ATL. Unlike the other HTLV-1 genes, the\n            <jats:italic>hbz<\/jats:italic>\n            gene is encoded on the complementary strand of the provirus and therefore is not under direct control of the promoter within the 5\u2032 long terminal repeat (LTR) of the provirus. This promoter can undergo inactivating genetic or epigenetic changes during the course of ATL that eliminates expression of all viral genes except that of\n            <jats:italic>hbz<\/jats:italic>\n            . In contrast, repressive modifications are not known to occur on the\n            <jats:italic>hbz<\/jats:italic>\n            promoter located in the 3\u2032 LTR, and\n            <jats:italic>hbz<\/jats:italic>\n            expression has been consistently detected in all ATL patient samples. Although Sp1 regulates basal transcription from the HBZ promoter, other factors that activate transcription remain undefined. In this study, we used a proviral reporter construct deleted of the 5\u2032 LTR to show that HBZ upregulates its own expression through cooperation with JunD. Activation of antisense transcription was apparent in serum-deprived cells in which the level of JunD was elevated, and elimination of JunD expression by gene knockout or shRNA-mediated knockdown abrogated this effect. Activation through HBZ and JunD additionally required Sp1 binding at the\n            <jats:italic>hbz<\/jats:italic>\n            promoter. These data favor a model in which JunD is recruited to the promoter through Sp1, where it heterodimerizes with HBZ thereby enhancing its activity. Separately,\n            <jats:italic>hbz<\/jats:italic>\n            gene expression led to an increase in JunD abundance, and this effect correlated with emergence of features of transformed cells in immortalized fibroblasts. Overall, our results suggest that JunD represents a novel therapeutic target for the treatment of ATL.\n          <\/jats:p>","DOI":"10.1128\/jvi.00661-12","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T03:02:34Z","timestamp":1339642954000},"page":"9070-9078","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3\u2032 Long Terminal Repeat"],"prefix":"10.1128","volume":"86","author":[{"given":"H\u00e9l\u00e8ne","family":"Gazon","sequence":"first","affiliation":[{"name":"CPBS, CNRS UMR 5236, Montpellier, France"},{"name":"CPBS, Universit\u00e9 Montpellier 1, Montpellier, France"},{"name":"Laboratoire de Virologie-Immunologie JE2503, Centre Hospitalier et Universitaire de Fort de France, Fort de France, Martinique, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Lemasson","sequence":"additional","affiliation":[{"name":"East Carolina University, Department of Microbiology and Immunology, Greenville, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Polakowski","sequence":"additional","affiliation":[{"name":"East Carolina University, Department of Microbiology and Immunology, Greenville, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"C\u00e9saire","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie-Immunologie JE2503, Centre Hospitalier et Universitaire de Fort de France, Fort de France, Martinique, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Barbeau","sequence":"additional","affiliation":[{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, D\u00e9partement des Sciences Biologiques, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Mesnard","sequence":"additional","affiliation":[{"name":"CPBS, CNRS UMR 5236, Montpellier, France"},{"name":"CPBS, Universit\u00e9 Montpellier 1, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Jean-Marie","family":"Peloponese","sequence":"additional","affiliation":[{"name":"CPBS, CNRS UMR 5236, Montpellier, France"},{"name":"CPBS, Universit\u00e9 Montpellier 1, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834524100"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-154286"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702279200"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.9.2056"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/v3050456"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.1.337-344.1997"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307275200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-321364"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00120-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.24.13848-13864.2004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-3-15"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803116200"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.04.003"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007035"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1209"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/08892220050193029"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.12813-12822.2002"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.08.025"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2741\/2163"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.9.3720"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb03525.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl375"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/08892220050193074"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1588"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802527200"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81148-4"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.41.29572"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.18.9389-9397.2002"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-4-92"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01264-08"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00480-06"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-6-71"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.537"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204381"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.15.6977-6988.2001"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-007732"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02511-06"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.14.9346-9350.2005"},{"key":"e_1_3_2_40_2","first-page":"3915","article-title":"Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells","volume":"95","author":"Mori N","year":"2000","unstructured":"MoriN. 2000. Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells. Blood 95:3915\u20133921.","journal-title":"Blood"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.5.2495-2505.2006"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.07087"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1385\/IR:34:1:1"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90513-4"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(74)90457-7"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.5.1500"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-6-19"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090236"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507631103"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2009.12.008"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0502-e131"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.68.1.821"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00555-07"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi274"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20007"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.3065.bloodjournal8883065"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-2-64"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(04)00225-X"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(98)00170-2"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2009.01.001"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00109-X"},{"key":"e_1_3_2_62_2","first-page":"21","article-title":"AP-1 derived from mature monocytes and astrocytes preferentially interacts with the HTLV-1 promoter central 21-bp repeat","volume":"11","author":"Wessner R","year":"1997","unstructured":"WessnerR WigdahlB. 1997. AP-1 derived from mature monocytes and astrocytes preferentially interacts with the HTLV-1 promoter central 21-bp repeat. Leukemia 11(Suppl 3):21\u201324.","journal-title":"Leukemia"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.1.188"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206898"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0937-1"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00242-08"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00661-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00661-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:14:42Z","timestamp":1646493282000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00661-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":65,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1128\/JVI.00661-12"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00661-12","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"2012-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}