{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:09:35Z","timestamp":1773972575549,"version":"3.50.1"},"reference-count":53,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201400006C"],"award-info":[{"award-number":["HHSN272201400006C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Extreme geographic and cultural isolation can still be found in some indigenous South American villages. Such isolation may be expected to limit the introduction of otherwise common and widely distributed viruses. Very small population sizes may also result in rapid local viral extinction due to a lack of seronegative subjects to maintain transmission chains for rapidly cleared viruses. We compared the viruses in the nasal passages of young children in three villages with increasing levels of geographic isolation. We found that isolation did not reduce the overall diversity of viral infections. Multiple infections with nearly identical rhinoviruses could be detected within each village, likely reflecting recent viral introductions and transmission clusters among epidemiologically linked members of these very small communities. We conclude that, despite their geographic isolation, remote indigenous villages show evidence of ongoing exposure to globally circulating viruses.<\/jats:p>","DOI":"10.1128\/jvi.00681-19","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T11:37:37Z","timestamp":1560253057000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Geographic Isolation on the Nasal Virome of Indigenous Children"],"prefix":"10.1128","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7903-6986","authenticated-orcid":false,"given":"Eda","family":"Altan","sequence":"first","affiliation":[{"name":"Vitalant Research Institute, San Francisco, California, USA"},{"name":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Dib","sequence":"additional","affiliation":[{"name":"Universidad del Norte, Barranquilla, Atlantico, Colombia"},{"name":"Fundaci\u00f3n Salud Para el Tr\u00f3pico-Tropical Health Foundation, Santa Marta, Magdalena, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres Rojas","family":"Gulloso","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Salud Para el Tr\u00f3pico-Tropical Health Foundation, Santa Marta, Magdalena, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duamaco","family":"Escribano Juandigua","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Salud Para el Tr\u00f3pico-Tropical Health Foundation, Santa Marta, Magdalena, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xutao","family":"Deng","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute, San Francisco, California, USA"},{"name":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Bruhn","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute, San Francisco, California, USA"},{"name":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Freiden","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janie","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute, San Francisco, California, USA"},{"name":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey","family":"Schultz-Cherry","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Delwart","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute, San Francisco, California, USA"},{"name":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.163483"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112563108"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep14032"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06502-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Altan E Dib JC Gulloso AR Escribano Juandigua D Deng X Bruhn R Hildebrand K Freiden P Yamamoto J Schultz-Cherry S Delwart E. 2019. 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