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Although effective antiviral T cell immunity and development of viral hepatitis are strictly dependent on perforin and granzymes, the molecular basis underlying induction of functionally competent virus-immune T cells, including participation of the innate immune system, is far from being resolved. We demonstrate here that LCMV-immune T cells of interleukin-1 receptor (IL-1R)-deficient mice readily express transcripts for perforin and granzymes but only translate perforin, resulting in the lack of proapoptotic potential<jats:italic>in vitro<\/jats:italic>. LCMV is not cleared in IL-1R-deficient mice, and yet the infected mice develop neither splenomegaly nor hepatitis. These results demonstrate that IL-1R signaling is central to the induction of proapoptotic CD8 T cell immunity, including viral clearance and associated tissue injuries in LCMV infection.<\/jats:p>","DOI":"10.1128\/jvi.00682-12","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T01:11:02Z","timestamp":1339031462000},"page":"8713-8719","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Interleukin-1R Signaling Is Essential for Induction of Proapoptotic CD8 T Cells, Viral Clearance, and Pathology during Lymphocytic Choriomeningitis Virus Infection in Mice"],"prefix":"10.1128","volume":"86","author":[{"given":"Lars T.","family":"Joeckel","sequence":"first","affiliation":[{"name":"Metschnikoff Laboratory, Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"},{"name":"Institute of Molecular Medicine and Cell Research, Albert Ludwig University, Freiburg, Germany"},{"name":"GRK1104, Freiburg, Germany"},{"name":"Spemann Graduate School of Biology and Medicine, Albert Ludwig University, Freiburg, Germany"},{"name":"Faculty of Biology, Albert Ludwig University, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Wallich","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Immunologie, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil S.","family":"Metkar","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystems Research Institute, University of Chicago School of Medicine, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Froelich","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystems Research Institute, University of Chicago School of Medicine, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M.","family":"Simon","sequence":"additional","affiliation":[{"name":"Metschnikoff Laboratory, Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Borner","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine and Cell Research, Albert Ludwig University, Freiburg, Germany"},{"name":"Spemann Graduate School of Biology and Medicine, Albert Ludwig University, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80596-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.07.037"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(91)90021-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000430"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.18.8781-8791.2001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.004960-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902745106"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804333"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.4049\/jimmunol.162.6.3256","article-title":"Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells","volume":"162","author":"Curtsinger JM","year":"1999","unstructured":"CurtsingerJM. 1999. 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