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The viral polymerase is a protein complex which is responsible for transcription and replication of the viral genome and therefore is an attractive target for antiviral drug development. For that purpose it is important to understand the mechanisms of how the virus replicates its genome and how the viral polymerase works on a molecular level. In this report, we characterize the role of the flexible surface-exposed PA\n            <jats:sup>51-72<\/jats:sup>\n            -loop in polymerase function and offer new insights into the replication mechanism of influenza A viruses.\n          <\/jats:p>","DOI":"10.1128\/jvi.00687-18","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T11:27:57Z","timestamp":1528284477000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["The Surface-Exposed PA\n            <sup>51-72<\/sup>\n            -Loop of the Influenza A Virus Polymerase Is Required for Viral Genome Replication"],"prefix":"10.1128","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-7837","authenticated-orcid":false,"given":"Benjamin E.","family":"Nilsson-Payant","sequence":"first","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, Oxford, United 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