{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:29:58Z","timestamp":1790267398223,"version":"4.1.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"22","license":[{"start":{"date-parts":[[2009,11,15]],"date-time":"2009-11-15T00:00:00Z","timestamp":1258243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2009,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Little is known about the in vivo kinetics of T-cell responses in smallpox\/monkeypox. We showed that macaque V\u03b32V\u03b42 T cells underwent 3-week-long expansion after smallpox vaccine immunization and displayed simple reexpansion in association with sterile anti-monkeypox virus (anti-MPV) immunity after MPV challenge. Virus-activated V\u03b32V\u03b42 T cells exhibited gamma interferon-producing effector function after phosphoantigen stimulation. Surprisingly, like \u03b1\u03b2 T cells, suboptimally primed V\u03b32V\u03b42 T cells in vaccinia virus\/cidofovir-covaccinated macaques mounted major recall-like expansion after MPV challenge. Finally, V\u03b32V\u03b42 T cells localized in inflamed lung tissues for potential regulation. Our studies provide the first in vivo evidence that viruses, despite their inability to produce exogenous phosphoantigen, can induce expansion, reexpansion, and recall-like expansion of V\u03b32V\u03b42 T cells and stimulate their antimicrobial cytokine response.<\/jats:p>","DOI":"10.1128\/jvi.00689-09","type":"journal-article","created":{"date-parts":[[2009,9,10]],"date-time":"2009-09-10T00:45:40Z","timestamp":1252543540000},"page":"11959-11965","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Expansion, Reexpansion, and Recall-Like Expansion of V\u03b32V\u03b42 T Cells in Smallpox Vaccination and Monkeypox Virus Infection"],"prefix":"10.1128","volume":"83","author":[{"given":"Lingyun","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, Chicago, Illinois"},{"name":"Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Shen","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/444423"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/503438"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.12.8287"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.11.007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1593"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00032-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030235"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00483-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1261"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2494(96)89648-9"},{"key":"e_1_3_2_12_2","first-page":"837","volume":"113","year":"2008","unstructured":"Gong, G., L. Shao, Y. Wang, C. Y. Chen, D. Huang, S. Yao, X. Zhan, H. Sicard, R. Wang, and Z. W. Chen. 2008. Phosphoantigen-activated V\u03b32V\u03b42 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells. Blood113:837-845.","journal-title":"Blood"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.9.4433-4443.2004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811250106"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01008-07"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/509823"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.5.3057"},{"key":"e_1_3_2_18_2","first-page":"1317","volume":"112","year":"2008","unstructured":"Pitard, V., D. Roumanes, X. Lafarge, L. Couzi, I. Garrigue, M. E. Lafon, P. Merville, J. F. Moreau, and J. Dechanet-Merville. 2008. Long-term expansion of effector\/memory V\u03b42-\u03b3\u03b4 T cells is a specific blood signature of CMV infection. Blood112:1317-1324.","journal-title":"Blood"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/502975"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283117f18"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v25.i1.10"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068819"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5471"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7845-7851.2005"},{"key":"e_1_3_2_25_2","first-page":"1115","volume":"83","year":"2008","unstructured":"Wei, H., D. Huang, J. Fortman, R. Wang, L. Shao, and Z. W. 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