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These proteins are incorporated into virions and inhibit infection of target cells unless counteracted by viral antagonists such as HIV-1 Nef. The only other biological function with which these proteins have been associated is the formation of serine-containing membrane lipids. Here we show that SERINC5 is a glycosylated protein and that N-glycosylation is important for its steady-state expression. In the absence of N-glycosylation, SERINC5 is prone to proteasomal degradation. Nonetheless, N-glycosylation<jats:italic>per se<\/jats:italic>is required neither for the ability of SERINC5 to inhibit HIV-1 infectivity nor for its sensitivity to antagonism by Nef.<\/jats:p>","DOI":"10.1128\/jvi.00753-18","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T09:59:41Z","timestamp":1535623181000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["An N-Glycosylated Form of SERINC5 Is Specifically Incorporated into HIV-1 Virions"],"prefix":"10.1128","volume":"92","author":[{"given":"Shilpi","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California\u2014San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Lewinski","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California\u2014San Diego, La Jolla, California, USA"},{"name":"VA San Diego Healthcare System, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Guatelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California\u2014San Diego, La Jolla, California, USA"},{"name":"VA San Diego Healthcare System, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.06.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3156"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5238.988"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90097-I"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501263320405"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00109-17"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/34929"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/350508a0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02868-14"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.8.5048-5056.1995"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.5.2906-2914.1994"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.1502"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.1.101"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.1.579-584.1995"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.09.003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15399"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15400"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505712200"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612044113"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2017.12.005"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.082"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.777714"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02214-16"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.797332"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.4049\/jimmunol.148.10.3055","article-title":"Persistent productive HIV-1 infection of a CD4- human fetal thymocyte line","volume":"148","author":"Hatch WC","year":"1992","unstructured":"Hatch WC, Tanaka KE, Calcelli T, Rashbaum WK, Kress Y, Lyman WD. 1992. 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