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Latency-reversing agents tested in clinical trials to date have failed to affect the HIV viral reservoir. IL-15 superagonist N-803, currently involved in a clinical trial for HIV cure, was recently shown by our laboratory to induce robust and persistent induction of plasma viremia during ART in three\n                    <jats:italic>in vivo<\/jats:italic>\n                    animal models of HIV infection. These results suggest a substantial role for CD8\n                    <jats:sup>+<\/jats:sup>\n                    lymphocytes in suppressing the latency reversal effect of N-803 by promoting the maintenance of viral latency. In this study, we tested whether the use of a CD8\u03b2-targeting antibody, which would specifically deplete CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, would yield similar levels of virus reactivation. We observed the induction of plasma viremia, which correlated with the efficacy of the CD8 depletion strategy.\n                  <\/jats:p>","DOI":"10.1128\/jvi.00755-20","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T09:54:04Z","timestamp":1594634044000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["Combination of CD8\u03b2 Depletion and Interleukin-15 Superagonist N-803 Induces Virus Reactivation in Simian-Human Immunodeficiency Virus-Infected, Long-Term ART-Treated Rhesus Macaques"],"prefix":"10.1128","volume":"94","author":[{"given":"Julia B.","family":"McBrien","sequence":"first","affiliation":[{"name":"Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K. 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