{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:46:40Z","timestamp":1789519600650,"version":"build-2803163510"},"reference-count":110,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI079059"],"award-info":[{"award-number":["AI079059"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI131598"],"award-info":[{"award-number":["AI131598"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG058503"],"award-info":[{"award-number":["AG058503"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2023,7,27]]},"abstract":"<jats:p>Herpesviruses establish lifelong latent infections, which pose an important risk for disease particularly in the immunocompromised. Our work is focused on the betaherpesvirus human cytomegalovirus (HCMV) that latently infects the majority of the population worldwide.<\/jats:p>","DOI":"10.1128\/jvi.00758-23","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T14:01:14Z","timestamp":1687269674000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Liver X Receptor-Inducible Host E3 Ligase IDOL Targets a Human Cytomegalovirus Reactivation Determinant"],"prefix":"10.1128","volume":"97","author":[{"given":"Luwanika","family":"Mlera","sequence":"first","affiliation":[{"name":"Department of Immunobiology, University of Arizona, Tucson, Arizona, USA"},{"name":"BIO5 Institute, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Collins-McMillen","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona, Tucson, Arizona, USA"},{"name":"BIO5 Institute, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zeltzer","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona, Tucson, Arizona, USA"},{"name":"BIO5 Institute, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Buehler","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona, Tucson, Arizona, USA"},{"name":"BIO5 Institute, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Moy","sequence":"additional","affiliation":[{"name":"Graduate Interdisciplinary Program in Cancer Biology, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Zarrella","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Caviness","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona, Tucson, Arizona, USA"},{"name":"BIO5 Institute, University of Arizona, Tucson, Arizona, USA"},{"name":"Graduate Interdisciplinary Program in Genetics, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Cicchini","sequence":"additional","affiliation":[{"name":"BIO5 Institute, University of Arizona, Tucson, Arizona, USA"},{"name":"Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Tafoya","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona, Tucson, Arizona, USA"},{"name":"BIO5 Institute, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-7290","authenticated-orcid":true,"given":"Felicia","family":"Goodrum","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona, Tucson, Arizona, USA"},{"name":"BIO5 Institute, University of Arizona, Tucson, Arizona, USA"},{"name":"Graduate Interdisciplinary Program in Cancer Biology, University of Arizona, Tucson, Arizona, USA"},{"name":"Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Advances in virus research","author":"Goodrum F","year":"2022","unstructured":"Goodrum F. 2022. The complex biology of human cytomegalovirus latency and reactivation. In Kielian M, Roossinck M (ed), Advances in virus research, 1 ed, vol 112. Academic Press, New York, NY.","edition":"1"},{"key":"e_1_3_3_3_2","volume-title":"Fields virology: DNA viruses","author":"Goodrum F","year":"2022","unstructured":"Goodrum F, Britt W, Mocarski ES. 2022. Cytomegalovirus. In Howley PM, Knipe DM, Cohen JL, Damania BA (ed), Fields virology: DNA viruses, 7th ed, vol 2. Wolters Kluwer, Hagerstown, MD.","edition":"7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3937"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00368"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408994102"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01539-13"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-72-9-2059"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01560-18"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(01)80014-3"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05878-11"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005655"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235047"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06005-11"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05028-11"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02267-21"},{"key":"e_1_3_3_17_2","doi-asserted-by":"crossref","unstructured":"Zarrella K Longmire P Zeltzer S Collins-McMillen D Hancock M Buehler J Reitsma JM Terhune SS Nelson JA Goodrum F. 2023. Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection. bioRxiv. doi:10.1101\/2023.02.07.527452.","DOI":"10.1101\/2023.02.07.527452"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1501164"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03506-13"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00919-18"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008037"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01986-15"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02711-14"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007854"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.01.015"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00476"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009420117"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2002651117"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004195"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00682-18"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00986-20"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01469-10"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10846"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-021-07584-4"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01716-12"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.123729"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168974"},{"key":"e_1_3_3_38_2","doi-asserted-by":"crossref","unstructured":"Moy MA Collins-McMillen D Crawford L Parkins C Zeltzer S Caviness K Capozio P Goodrum F. 2023. UL135 and UL136 epistasis controls reactivation of human cytomegalovirus. bioRxiv. doi:10.1101\/2023.01.24.525282.","DOI":"10.1101\/2023.01.24.525282"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2001"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(03)01074-2"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-014-0131-3"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.250571"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.29178"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.698688"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6135.2004.00727.x"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-018-0937-3"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.05.012"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00843-19"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00167-21"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06467-11"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003266"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1900783116"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-016-0634-z"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.01.036"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.140.5.1625"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/v7062751"},{"key":"e_1_3_3_57_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1016-8478(23)13505-9","article-title":"Factors affecting human cytomegalovirus gene expression in human monocyte cell lines","volume":"9","author":"Lee CH","year":"1999","unstructured":"Lee CH, Lee GC, Chan YJ, Chiou CJ, Ahn JH, Hayward GS. 1999. Factors affecting human cytomegalovirus gene expression in human monocyte cell lines. Mol Cells 9:37\u201344.","journal-title":"Mol Cells"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1111-1_5"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2017.03.005"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7303"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.30.2.299"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.64.12.6154-6165.1990"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.65.2.887-896.1991"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.65.2.897-903.1991"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.707"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.06.042"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.1.266"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/383728a0"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0959-437x(98)80013-0"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.035600"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M062752"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073861"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.TR119000267"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.10.008"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-472x(98)00017-4"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20399"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4644(20010301)80:3%3C455::AID-JCB180%3E3.0.CO;2-Z"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111589108"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.846386"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20131442"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-2-14"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00373-11"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.3390\/v14030514"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01115-18"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02071-18"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.06.004"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092140"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-11-69"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.01.137"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00789-11"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-016-2950-4"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02727-13"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25501"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.09.024"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00860-1"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.03.004"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113060118"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005918"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2016.11.016"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091359"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.02.008"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511117103"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1584907"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2017.09.012"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000363"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.15.4299"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.04.007"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002444"},{"key":"e_1_3_3_109_2","first-page":"71","article-title":"An improvement of the 2^(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis","volume":"3","author":"Rao X","year":"2013","unstructured":"Rao X, Huang X, Zhou Z, Lin X. 2013. An improvement of the 2^(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis. Biostat Bioinforma Biomath 3:71\u201385.","journal-title":"Biostat Bioinforma Biomath"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1999.4085"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3047"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.00758-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.00758-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:26:57Z","timestamp":1729618017000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.00758-23"}},"subtitle":[],"editor":[{"given":"Stacey","family":"Schultz-Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":110,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7,27]]}},"alternative-id":["10.1128\/jvi.00758-23"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00758-23","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,27]]},"assertion":[{"value":"2023-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00758-23"}}